Results 111 to 120 of about 2,073,822 (317)

Correlates of muscle strength in diabetes The study on the assessment of determinants of muscle and bone strength abnormalities in diabetes (SAMBA)

open access: yes, 2014
Background and aims: Apart from late motor nerve dysfunction, factors affecting muscle strength in diabetes are largely unknown. This study was aimed at assessing muscle strength correlates in diabetic subjects encompassing a wide range of peripheral ...
S. Balducci   +13 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Material's Strength Analysis of the Coupling Node of Axle of the Truck Trailer. [PDF]

open access: yesMaterials (Basel), 2023
Decker Ž   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Measuring implementation strength: Literature review draft report 2012 [PDF]

open access: yes, 2012
Measuring implementation strength (sometimes referred to as implementation intensity) is an important programme evaluation process which helps to understand why some programmes are successful and some fail, attribute outcomes to a programme, and ...
Schellenberg, JA, Bobrova, N, Avan, BI
core  

STRENGTH PROPERTIES ANALYSIS OF J55 TUBING PREMIUM CONNECTION

open access: yes, 2016
Objective Analysis of torque screwing performance and four kinds of ultimate failure stress distribution of the J55 high strength no shoulder tubing premium connection,the inner wall of the tubing connection is smooth and alignment in favor of the ...
WANG Ke   +4 more
core   +1 more source

ANALYSIS OF THE CONSTRUCTION OF THE CAR TRAILER FRAME IN TERMS OF CHANGING THE ASSEMBLY TECHNOLOGY

open access: yesScientific Journal of Silesian University of Technology. Series Transport
Car trailers are quite a popular means of transport and are offered in many versions, from single axle light trailers with a maximum permissible weight of 750 kg, through two- or more-axle specialized trailers.
Jacek CABAN   +4 more
doaj   +1 more source

Optimization Design and Experimental Verification of Type B Bogie Frame Structure Based on Workbench

open access: yes机车电传动, 2019
In order to make the structure strength of the bogie frame meet the requirements of the standard in the design stage, the finite element method and the optimization design theory were combined to optimize the structure design. Firstly, the finite element
Ming ZHANG, Pengpeng ZHI
doaj  

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