Results 91 to 100 of about 5,546,929 (302)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Strength analysis and structural optimization of UAV airframe

Frontiers in Mechanical Engineering
IntroductionWith the booming low-altitude economy, UAVs drive transformative changes across sectors, but their design must balance lightweight demands and structural integrity.
Longhai Ye, Yanpeng Zhao, Haifeng Zhang, Yao Zhang, Jiming Lv, Zonghan Yang   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mesoscopic Analysis of Structure and Strength of Dislocation Junctions in FCC Metals

, 1999
We develop a finite element based dislocation dynamics model to simulate the structure and strength of dislocation junctions in FCC crystals. The model is based on anisotropic elasticity theory supplemented by the explicit inclusion of the separation of ...
A. Korner, D. J. Bacon, D. Rodney, G. Saada, G. Schoeck, H. P. Karnthaler, J. L. Bassani, J. P. Hirth, J. P. Hirth, J. P. Hirth, K. W. Schwarz, L. K. Wickham, M. S. Duesbery, M. Verdier, P. Franciosi, R. Phillips, R. V. Kukta, S. J. Zhou, T. Jossang, V. B. Shenoy, V. Bulatov   +20 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

GCY300II Type Rail Car Bogie Frame Strength Analysis and Structural Improvement

机车电传动, 2012
GCY300II rail car bogie frame structural features were described. With TB/T 1335 — 1996, simulation framework for static strength and dynamic stress test were carried out, and correctness of the simulation model was verified by comparative analysis ...
LI Rui-xia, QI Shuang-qiang
doaj  

Magnetic fields in molecular clouds: Limitations of the analysis of Zeeman observations

, 2017
Context. Observations of Zeeman split spectral lines represent an important approach to derive the structure and strength of magnetic fields in molecular clouds.
Brauer, R., Ober, F., Reissl, S., Wolf, S.   +3 more
core   +1 more source

Strength in Diversity: The Advance of Data Analysis [PDF]

, 2004
The scientific analysis of data is only around a century old. For most of that century, data analysis was the realm of only one discipline - statistics. As a consequence of the development of the computer, things have changed dramatically and now there are several such disciplines, including machine learning, pattern recognition, and data mining.
openaire   +2 more sources