Results 91 to 100 of about 26,250,209 (255)

Extrapolation and Application of Standard EN 13749 in Strength Analysis of Locomotive Axle-Box Body

open access: yes机车电传动, 2013
According to existing standards for axle-box test not covering check and analysis of axle-box body, application scope, force types, and load cases were compared among several test standards for bogie frames. It was revealed that standard EN 13749 had the
XIAO Shou-ne   +3 more
doaj  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Shear Strength of Granular Materials with Dispersed and Non-Dispersed Oversized Particles [PDF]

open access: yes, 2013
Soils containing dispersed and non-dispersed large particles (greater than # 4 sieve) form part of many engineered fills, glacial tills, debris flows, and residual soil deposits.
Seminsky, Leanna
core  

Analysis and Inspection for CRH3 EMUs Cooling FanSupport Frame Structural Strength

open access: yes机车电传动, 2014
Aimed at the cooling fan failures of CRH3 EMUs, combined the train vibration condition, conducted modal analysis andstrength analysis of the cooling fan were carried out based on the finite element software.
YANG Xu, LIU Shu-hai, GUO Dan
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

STRUCTURAL STRENGTH AND RELIABILITY ANALYSIS OF MW SCALE WIND TURBINE’S MAIN SHAFT

open access: yes, 2019
The parametric FE model of the main shaft for a 1.5 MW doubly-fed wind turbine was established with parametric language APDL of ANSYS in a command stream file.
LI ZhiQiang, ZHOU XinJian, LI GuangXing
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

FATIGUE STRENGTH ANALYSIS OF HIGH-STRENGTH JOINT BOLTS UNDER MULTIAXIAL NONPROPORTIONAL LOADING SPECTRUM

open access: yes, 2019
A method about fatigue strength analysis of high-strength joint bolts was proposed on the background of gearbox housing joint design of the wind turbine. The method was based on the theory of multi-axial fatigue. And the calculation process of the method
CAO FaJun
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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