Results 91 to 100 of about 1,763,815 (268)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Static Strength Analysis and Optimization of the Roller Cone Bit Bearing Structure

Shiyou jixie, 2015
The tricone bit is prone to having a failure bearing under high WOB and high RPM.To improve the roller cone bit bearing structure stress,increase the tooth placement space and the thickness of the shell,a three dimensional model has been established ...
Li Bin, Yang Shuang, Shen Huanyu, Zhang Dongyang   +3 more
doaj  

A Simplified Dynamic Strength Analysis of Cardboard Packaging Subjected to Transport Loads. [PDF]

Materials (Basel), 2023
Mrówczyński D, Gajewski T, Garbowski T.   +2 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Structural strength analysis of a rotary drum mower during harvesting

Journal of Agricultural Engineering
A Rotary Drum Mower (RDM) is a tractor-mounted mechanism used for harvesting green fodder crops. It faces dynamic forces from rough field surfaces and cutting resistance, posing design challenges and potential failures. This study aims to present a well-
Kursat H. Celik, Ibrahim Akinci, Nuri Caglayan, Allan E.W. Rennie   +3 more
doaj   +1 more source

Numerical Strength Analysis of Laser-Welded Differential Housing and Gear Considering Residual Stress. [PDF]

Materials (Basel), 2023
Wang L, Ni Z, Xiao Y, Li Y, Liu X, Chen Y, Cui S, Zhang D, Mi C, He Q.   +9 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Flexural Strength Analysis of Different Complete Denture Resin-Based Materials Obtained by Conventional and Digital Manufacturing. [PDF]

Materials (Basel), 2023
Casucci A, Verniani G, Barbieri AL, Ricci NM, Ferrari Cagidiaco E, Ferrari M.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mathematical Modeling of the Load of an Open Wagon Body with Corrugated Sheet Metal

Mathematics
This article presents mathematical modeling results in terms of the load-bearing properties of an open wagon body with corrugated sheet metal. The main hypothesis of this study is that the use of corrugated sheet metal will improve wall cladding strength
Juraj Gerlici, Alyona Lovska, Mykhailo Pavliuchenkov, Ján Dižo, Pavol Šťastniak   +4 more
doaj   +1 more source