Results 71 to 80 of about 2,073,822 (317)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2008 The hull girder ultimate strength of a typical bulk carrier is analyzed using a simplified method based on an incremental-iterative approach. First, vertical bending moment is examined by seven different methods.
Barltrop, Nigel, Ozguc, Ozgur
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Design of Large Torque Combined PDM for Pipeline Laying Trenchless Technology
Shiyou jixie, 2018 At present, PDM is mainly used to provide torque for the reaming bit in the trenchless technique for pipeline laying. However, owing to the limited torque provided by the existing PDM, multiple reaming operations are needed to achieve the requirements ...
Zhang Jie, Liang Zheng, Han Chuanjun
doaj
Studia Geotechnica et Mechanica, 2018 The article presents a comparison of the roadway supports currently used in mines in the Soma basin in Turkey with new one proposed by Huta Łabędy and Central Mining Institute (GIG) in terms of resistance parameters and work in conditions of specific ...
Grodzicki Marek, Rotkegel Marek
doaj +1 more source
LDA-Based Topic Strength Analysis
Computing and Informatics, 2017 Topic strength is an important hotspot in topic research. The evolution of topic strength not only indicates emerging new topics, but also helps us to determine whether a topic will produce some fluctuation of topic strength over time. Thus, topic strength analysis can provide significant findings in public opinion monitoring and user personalization ...
Jiamiao Wang +2 more
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Static Strength Analysis and Optimization of the Roller Cone Bit Bearing Structure
Shiyou jixie, 2015 The tricone bit is prone to having a failure bearing under high WOB and high RPM.To improve the roller cone bit bearing structure stress,increase the tooth placement space and the thickness of the shell,a three dimensional model has been established ...
Li Bin +3 more
doaj
Aerodynamic design and strength check of a two-stage dual-rotor opposed centrifugal compressor
Zhongguo Jianchuan Yanjiu, 2019 [Objectives] To accomplish the design of a two-stage dual-rotor opposed centrifugal compressor for a small gas turbine,[Methods] the compressor is subject to aerodynamic design and three-dimensional flow field check by using the software Concepts NREC ...
Geng Shaojuan +4 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source