Results 101 to 110 of about 1,453,882 (351)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Ground and excited states Gamow-Teller strength distributions of iron isotopes and associated capture rates for core-collapse simulations

, 2012
This paper reports on the microscopic calculation of ground and excited states Gamow-Teller (GT) strength distributions, both in the electron capture and electron decay direction, for $^{54,55,56}$Fe.
A. Heger, A. Staudt, B.D. Anderson, C. Gaarde, C.D. Goodman, C.W. Johnson, D. Arnet, F. Osterfeld, G. Audi, G.M. Fuller, G.M. Fuller, G.M. Fuller, G.M. Fuller, G.P. Yost, H.A. Bethe, I. Stetcu, J. Krumlinde, J. Rapaport, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.-U. Nabi, J.A. Halbleib, Jameel-Un Nabi, K. Iwamoto, K. Langanke, K. Muto, K. Muto, M. Hirsch, M. Hirsch, M.B. Aufderheide, M.B. Aufderheide, M.C. Vetterli, P. Möller, S. El-Kateb, S. Raman, S.G. Nilsson, T. Rönnqvist, V. Rodin   +47 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

MATHEMATICAL MODELS OF THE INTERACTION OF STRUCTURES WITH LIQUID AND CALCULATIONS ON THE STRENGTH AND RESONANCE OF BLADE HYDRAULIC MACHINES

, 2023
Yurii Kukhtenkov, Sergiy Nazarenko
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Validity of approximations applied in calculations of single-wall metallic carbon nanotube current-voltage characteristics

, 2012
The calculation results of dependencies of electric current in the infinitely long single-wall metallic carbon nanotubes of armchair type with different diameter values on the strength of constant and uniform longitudinal electric field applied to them ...
Pozdnyakov, Dmitry
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

COMPARISON BETWEEN HB AND AGMA BEVEL GEAR STRENGTH CALCULATION STANDARD

Jixie qiangdu, 2015
In this paper similarities and differences in Bearing Capacity Calculation of Aviation Bevel Gears（ HB / Z89.1 HB / Z89.4-85） and Rating the Pitting Resistance and Bending Strength of Generated Straight Bevel,Zerol Bevel and Spiral Bevel Gear Teeth（ ANSI
LI XiangYu, LIU ShaoJun
doaj