Results 81 to 90 of about 1,529,754 (290)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Forward-backward multiplicity correlations in e+e- annihilation and pp collisions and the weighted superposition mechanism

, 2002
Forward-backward multiplicity correlations in symmetric collisions are calculated independently of the detailed form of the corresponding multiplicity distribution.
Giovannini, A., Ugoccioni, R.
core   +2 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Persistence in the Zero-Temperature Dynamics of the Diluted Ising Ferromagnet in Two Dimensions

, 1999
The non-equilibrium dynamics of the strongly diluted random-bond Ising model in two-dimensions (2d) is investigated numerically. The persistence probability, P(t), of spins which do not flip by time t is found to decay to a non-zero, dilution-dependent,
A. J. Bray, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Zheng, C. M. Newman, D. Stauffer, K. Oerding, S. Jain, S. Jain, S. N. Majumdar   +11 more
core   +2 more sources

Strength development in adolescents in physical education classes

International Physical Medicine & Rehabilitation Journal, 2019
Objective:The objective of this study was to gain muscle strength in all its variables in adolescents after a strength training program in physical education classes for a period of 12 weeks - a strength training program in physical education classes at a State School of Ponta Pora (Brazil) was applied.
Raphael Oliveira Ramos Franco Netto, Paulo Ricardo Cardoso Klidzio, Adriana Langer   +2 more
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Influence of composite fibers on the properties of heavy concrete

MATEC Web of Conferences, 2016
The article presents the results of research an effect of glass-plastic fiber on the properties of heavy concrete. It determined that adding glass-plastic fibers in heavy concrete compositions in an amount of 0.5 to 2.5 % by volume leads to decreasing of
Nurtdinov Marsel, Solovyev Vadim, Panchenko Alexander   +2 more
doaj   +1 more source

Advanced powder metallurgy aluminum alloys via rapid solidification technology, phase 2 [PDF]

Marko's rapid solidification technology was applied to processing high strength aluminum alloys. Four classes of alloys, namely, Al-Li based (class 1), 2124 type (class 2), high temperature Al-Fe-Mo (class 3), and PM X7091 type (class 4) alloy, were ...
Jha, Sunil C., Ray, Ranjan
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source