Results 51 to 60 of about 5,339,184 (298)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Effect of Using Different Aspect Ratios of Sustainable Copper Fiber on Some Mechanical Properties of High-Strength Green Concrete

Journal of Engineering, 2023
To achieve sustainability, use waste materials to make concrete to use alternative components and reduce the production of Portland cement. Lime cement was used instead of Portland cement, and 15% of the cement's weight was replaced with silica fume ...
Ahmed Najm Abdullah, Nada Mahdi Fawzi
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Strain aging on the yield strength to tensile strength ratio of UOE pipe

Materials Science and Technology, 2017
Strain aging of microalloyed steel pipe can occur at the relatively low temperatures associated with the pipe coating process and/or during long-term storage. A Box–Behnken statistical design was used to determine the significant strain aging variables that affect the longitudinal yield strength to tensile strength (Y/TS) ratio for three uncoated X70 ...
Wiskel, J.B., Ma, J., Valloton, J., Ivey, D.G., Henein, H.   +4 more
openaire   +2 more sources

A lack of sexual dimorphism in width-to-height ratio in White European faces using 2D photographs, 3D scans, and anthropometry [PDF]

, 2012
Facial width-to-height ratio has received a great deal of attention in recent research. Evidence from human skulls suggests that males have a larger relative facial width than females, and that this sexual dimorphism is an honest signal of masculinity,
Jones, Alex L., Robin S S Kramer, Kramer Robin S. S., Alex L Jones, Jones Alex L., Kramer, Robin S. S., Ward, Robert, Alex Jones, Ward Robert, Robert Ward   +9 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Study on Strength Failure Mechanism of Super-reduction Ratio Hypoid Gears

Jixie chuandong, 2022
Aiming at the problems of strength and fatigue of super-reduction ratio hypoid gears， a calculation of the gear blank parameters is completed， a three-dimensional assembly model is established， and a finite element simulation is carried out on the super ...
Yu Zhang, Peng Zhou, Zedong Li, Pei Liang, Zhiyong Wang   +4 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Combined training (aerobic plus strength) potentiates a reduction in body fat but demonstrates no difference on the lipid profile in postmenopausal women when compared to aerobic training with a similar training load

, 2015
The aim of this study was to verify the effects of aerobic and combined training on the body composition and lipid profile of obese postmenopausal women and to analyze which of these models is more effective after equalizing the training load. Sixty five
Papoti, Marcelo, Freitas Junior, Ismael F., Picolo, Malena R., Lira, Fabio S., Buonani, Camila, Kalva-Filho, Carlos A., Neves, Lucas M., Rossi, Fabrício E. [UNESP], Fortaleza, Ana C S, Rossi, Fabrício E., Diniz, Tiego A.   +10 more
core   +1 more source