Results 61 to 70 of about 5,339,184 (298)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Public policy failures related to China ́s Wind Power Development

, 2019
An anecdote about the failure of the Soviet economic system tells about a factory which were evaluated based on tons of nails produced – unsurprisingly the nails became heavy. China is currently hailed as the worlds primer wind power producer; however, a
Grafström, Jonas
core   +2 more sources

Brittle‐Ductile Rheological Behavior in Subduction Zones: Effects of Strength Ratio Between Strong and Weak Phases in a Bi‐Phase System

Geophysical Research Letters
The brittle‐ductile rheological behavior in subduction zones is commonly proposed to explain deep transient slips. Generally observed at large scales in tectonic “mélanges”, here we show that it is also observed at the grain scale in exhumed blueschist ...
A. Maitre, F. Gueydan, C. Thieulot, E. Oliot   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comparison of Knee Muscle Strength and Ankle Dorsiflexion Range of Motion Between Standing Workers With and Without Patellofemoral Pain Syndrome

Physical Therapy Korea, 2020
Background: Prolonged standing during work causes a lower extremity pain and disorders. Patellofemoral pain syndrome (PFPS) is one of the common diagnoses of the knee pain. Although the etiology of PFPS is not completely understood, it is considered to
Young-soo Weon, Sun-hee Ahn, Jun-hee Kim, Gyeong-tae Gwak, Oh-yun Kwon   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Comparing the Isometric Strength of the Shoulder and Scapulothoracic Muscles in Volleyball and Futsal Athletes

Physical Treatments, 2017
Purpose: This study aimed to evaluate the symmetry of the isometric strength of the shoulder and scapulothoracic muscles in volleyball and futsal athletes.
Afshin Rasouli, Aliashraf Jamshidi, Soheil Sohani   +2 more
doaj  

Proposal of a novel APPLE-KNOT undulator by selecting the KNOT field as the dominant magnetic field

Journal of Synchrotron Radiation
The APPLE-KNOT undulator forms composite magnetic fields by superimposing an APPLE field and a KNOT field with different period lengths, in which one serves as the dominant field to approach the target photon energy and the other acts as an additional ...
Binghao Zhang, Chao Chen, Yuanfang Xu, Zhouyu Zhao, Heting Li   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Numerical Analysis for the Progressive Failure of Binary-Medium Interface under Shearing

Advances in Civil Engineering, 2018
Binary-medium specimens were fabricated using the particle flow code, and the shear strength, dilatancy, and failure behavior of the binary-medium specimens with different bond strength ratios (0.25, 0.5, 0.75, and 1.0) under different normal stresses ...
Rihong Cao, Wenyu Tang, Hang Lin, Xiang Fan   +3 more
doaj   +1 more source