Results 51 to 60 of about 183,398 (265)

The strengthening mechanism synergy of heat-treated 3D printed Al-Sc alloy

Virtual and Physical Prototyping, 2023
According to the material nature, aluminium alloys are widely applied in aerospace, construction and automotive applications due to their characteristics, such as lightweight, good formability and good corrosion resistance.
Che-Nan Kuo, Po-Chun Peng
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mechanical properties and strengthening mechanism of medium and high volume fraction SiCp/Al composites

Cailiao gongcheng
The medium and high volume fraction SiCp/Al composites were prepared by hot isostatic pressing powder metallurgy process with volume fractions of 35%, 45% and 55% using 2024 and 6061 aluminum alloys as the matrix, respectively. The effect of matrix alloy
CUI Yan, LIAO Jiajie, CAO Leigang, YANG Yue   +3 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Research progress in additive manufacturing of AlCoCrFeNi2.1 eutectic high-entropy alloys

Cailiao gongcheng
AlCoCrFeNi2.1 eutectic high-entropy alloy is characterized by a fine, homogeneous, and regular lamellar structure, as well as good organizational structure and mechanical properties with both strength and plasticity over a wide range of temperature (70 ...
QIU Hefang, YUAN Xiaojing, LUO Weipeng, ZHANG Ze, CHENG Chen, CUI Fanfan   +5 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Microstructure evolution and thermodynamic mechanisms in an oxide-dispersed Fe–Ni–Ti–Mo maraging steel

Virtual and Physical Prototyping
Laser powder bed fusion (LPBF) enables the fabrication of ultrahigh-strength steels with tailored microstructures through intrinsic thermal cycling. Here, an oxide-dispersed Fe–Ni–Ti–Mo maraging steel was produced by dielectrophoretically depositing Y2O3
Wei Li, Bowen Shi, Yuping Zhu, Liangyin Xiong, Wei Yan, Mengchao Niu, Wei Wang   +6 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source