Results 201 to 210 of about 938,342 (303)

Invasive group B streptococcal infections in Western Australia, 2000-2018. [PDF]

Intern Med J
Wright CM, Moorin R, Dyer J, Carapetis J, Manning L.   +4 more
europepmc   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Autoimmune neuropsychiatric sequelae of group A streptococcal infections in Aboriginal and Torres Strait Islander people: an overlooked burden? [PDF]

Australas Psychiatry
Ketheesan S, Wade V, Hung TY, Roberts KV.   +3 more
europepmc   +1 more source

Putative trait‐based retention of oral‐derived microbes along the oral–gut axis in bamboo‐eating pandas

iMetaOmics, EarlyView.
Compared with the two herbivorous comparison species, pandas showed higher estimated oral‐source contributions and enrichment of microbial traits associated with facultative anaerobiosis, biofilm formation, and stress tolerance. These patterns are consistent with a model in which greater oral microbial input and putative host filtering may jointly ...
Lu Huang, Xiaoci Fan, Xinyue Tian, Yiying Wu, Yue Liu, Wei Wei, Honglin Wu, Lifeng Zhu   +7 more
wiley   +1 more source

Ordered assembly of Cas12a for better performance of CRISPR/Cas system with application to the diagnosis of dental caries

Interdisciplinary Medicine, EarlyView.
Here, we present a tetrahedral DNA framework (TDF)‐mediated Cas12a ordered assembly strategy. TDFs arrange CRISPR/Cas12a into ordered structures controllably, enhancing catalytic efficiency through localized Cas12a hotspots while maintaining spatial intervals to facilitate substrate diffusion.
Yining Zhao, Panpan Qiao, Yujing Zeng, Murtaza Sayed, Qin Mi, Juan Zhang, Genxi Li   +6 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Group B streptococcal infections in pregnancy and early life. [PDF]

Clin Microbiol Rev
Manuel G, Twentyman J, Noble K, Eastman AJ, Aronoff DM, Seepersaud R, Rajagopal L, Adams Waldorf KM.   +7 more
europepmc   +1 more source

The Impact of Immunoglobulins on Cardiovascular Diseases and Lipid Profiles in Elderly and Middle‐Aged Chinese Individuals: A 15‐Year Retrospective Study

Journal of Clinical Laboratory Analysis, EarlyView.
In a 15‐year retrospective study of Chinese adults over 45, we explored the links between immunoglobulins, CVDs, and lipid profiles. Temporal increases in IgG and IgA were positively associated with FFAs, offering new insights into humoral immunity and lipid metabolism, suggesting a mechanistic link between humoral immunity and dyslipidemia ...
Ya Li, Li Jiao, Yuan Gao, Xue‐Feng Ni
wiley   +1 more source

Risk of Household Secondary Invasive Group A Streptococcal Infections After a Prophylaxis Policy Change.

JAMA Netw Open
de Gier B, Vlaminckx BJM, van Roon A, Knol MJ, Te Wierik MJM, Notermans DW, de Melker HE, van Sorge NM.   +7 more
europepmc   +1 more source

The role of previous streptococcal infections in adult patients with obsessive-compulsive disorder: a research study. [PDF]

CNS Spectr
Marazziti D, Palermo S, Arone A, Carbone MG, Massa L, Crowther LF, Crivelli NSB, Gurrieri R, Weiss F, Mucci F, Dell'Osso L.   +10 more
europepmc   +1 more source