Results 21 to 30 of about 407,256 (265)

Molecular basis of pathogenic parasitic infections: insights from parasite kinome

Frontiers in Bioscience-Landmark, 2020
Infectious diseases caused by numerous parasitic pathogens represent a global health conundrum. Several animal and plant pathogens are responsible for causing acute illness in humans and deadly plant infections.
Sheeza Khan, Rishabh Kaushik, Meesha Sharma, Neha Raina, Faizan Ahmad, Asimul Islam   +5 more
doaj   +1 more source

Utility of rapid antigen detection test in group A ßhaemolytic streptococcal pharyngitis at a tertiary hospital, Gombe, North-East, Nigeria

Nigerian Journal of Paediatrics, 2023
Background: Throat swab cultures still remain the gold standard for the confirmation of Group A Streptococcal (GAS) pharyngitis but Rapid Antigen detection Test (RADT) are increasingly becoming popular.
Ahmad Adamu Girbo , Iliya Jalo , Isaac W. Elon, Rasaki Aliu   +3 more
doaj  

Tonsilities – symptoms, causes and diagnosis

Journal of Education, Health and Sport, 2019
Diseases of the throat and tonsils are one of the most frequent causes of patient visits to pediatricians and family doctors. It should be emphasized that to protect the vast majority of them, symptomatic management is sufficient.
Jacek Przybyłowski, Anna Fabian-Danielewska   +1 more
doaj   +1 more source

Post-Streptococcal Uveitis

Journal of Ophthalmology, 2020
Post-streptococcal uveitis refers to the most severe inflammatory conditions of the eye. It often affects young people leading to incapacity for work and physical disability.
Konovalova N.V., Savko V.V., Khramenko N.I., Guzun O.V., Slobodianyk S.B., Zhuravok Iu.A., Savko V.V.   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A case of phlegmonous gastritis complicated by stomach necrosis requiring gastrectomy

Gastroenterology & Endoscopy
Phlegmonous Gastritis (PG) is a rare and swiftly progressing disease that is often fatal. It typically involves severe invasion of the gastric wall by bacteria. Due to its vague symptoms, diagnosis is often delayed.
Karimulla S. Shaik, Mohamad Y. Khatib, Saibu George, Solaiman M. Allafi, Mohamed Z. Peediyakkal, Nevin Kannappilly, Abdulqadir J. Nashwan   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source