Results 291 to 300 of about 468,046 (357)

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

open access: yesChemCatChem, EarlyView.
Prodrug C is a water soluble, monomeric compound accumulating in mitochondria of cancer cells, where it is activated in the reaction with mitochondrial H2O2. The activation leads to the release of camptothecin that causes cell cycle arrest in G2 phase and cancer cell death.
Michael Raucheisen   +7 more
wiley   +1 more source

Swabs versus native specimens in severe head and neck infections: a prospective pilot study and suggestions for clinical management. [PDF]

open access: yesOral Maxillofac Surg
Neckel N   +10 more
europepmc   +1 more source

Recent cutting‐edge technologies for the delivery of peptide nucleic acid.

open access: yesChemistry – A European Journal, Accepted Article.
Peptide nucleic acids (PNAs) have garnered significant attention due to their enhanced chemical, physical, and binding properties in comparison to natural nucleic acids. This prompted their application in antigene/antisense approach, assigning them a pivotal role in gene editing and, more recently, showing their potential as “bilingual” molecules being
Concetta Avitabile   +4 more
wiley   +1 more source

Quantification of <i>Streptococcus salivarius</i> using the digital polymerase chain reaction as a liver fibrosis marker. [PDF]

open access: yesWorld J Hepatol
Iwasaki S   +10 more
europepmc   +1 more source

Solvent‐Free Process for Preparing Metal‐Organic Framework Composites Based on Carbon‐Based Quantum Dots and Their Derivatives as Drug Delivery Systems for Andrographolide

open access: yesChemistry – A European Journal, EarlyView.
Andrographolide (ADG) was conjugated with MOFs (MIL‐53(Al), ZIF‐8) carbon‐based quantum dots (CBQDs) and doped carbon‐based quantum dots (D‐CBQDs) using the green approach of high‐pressure (0.3 GPa) solid phase contact. This method enhances the drug solubility, as indicated by changes in hydrophobicity observed via 1H NMR. Abstract Andrographolide (ADG)
Wenndy Pantoja‐Romero   +5 more
wiley   +1 more source

Design of potent mannose‐6‐phosphate derivatives as ligands for CI‐M6P/IGF2R using fluorescence polarization assay

open access: yesChemistry – A European Journal, Accepted Article.
The cation‐independent mannose‐6‐phosphate/IGF2 receptor (CI‐M6P/IGF2R) plays a crucial role in transporting lysosomal enzymes and other ligands. In this study, we designed and synthesized novel, stable mannose‐6‐phosphate (M6P) derivatives to enhance their affinity for CI‐M6P/IGF2R.
Lucie Mrázková   +11 more
wiley   +1 more source

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