Results 31 to 40 of about 9,607 (263)

Acute multiple brain infarctions associated with Streptococcus suis infection: a case report

BMC Infectious Diseases
Streptococcus suis is one of the most common zoonotic pathogens, in humans and can cause meningitis, endocarditis, arthritis and sepsis. Human cases of Streptococcus suis infection have been reported worldwide, and most of those cases occurred in Asia ...
Wenxin Wei, Zhenhu Qiao, Donghua Qin, Yu Lan   +3 more
doaj   +1 more source

Exogenous methionine contributes to reversing the resistance of Streptococcus suis to macrolides

Microbiology Spectrum
Streptococcus suis (S. suis) has been increasingly recognized as a porcine zoonotic pathogen that threatens the health of both pigs and humans. Multidrug-resistant Streptococcus suis is becoming increasingly prevalent, and novel strategies to treat ...
Chun-Liu Dong, Tong Wu, Yue Dong, Qian-Wei Qu, Xue-Ying Chen, Yan-Hua Li   +5 more
doaj   +1 more source

Evolution and diversity of the antimicrobial resistance associated mobilome in Streptococcus suis: a probable mobile genetic elements reservoir for other streptococci

Frontiers in Cellular and Infection Microbiology, 2016
Streptococcus suis is a previously neglected, newly emerging multidrug-resistant zoonotic pathogen. Mobile genetic elements (MGEs) play a key role in intra- and interspecies horizontal transfer of antimicrobial resistance (AMR) determinants.
Jinhu Huang, Jiale Ma, Kexin Shang, Xiao Hu, Yuan Liang, Daiwei Li, Zuowei Wu, Lei Dai, Li Chen, Liping Wang   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PCR detection of haemolysin gene of Streptococcus suis type 2

浙江大学学报. 农业与生命科学版, 2004
A PCR assay for rapid and sensitive detection of haemolysin of Streptococcus suis type 2 was established. The PCR primers based on the haemolysin of S. suis type 2 succeeded in amplifying a 1502 bp PCR product.
MA You-zhi, LI Xiao-liang, FANG Wei-huan
doaj   +1 more source

Susceptibility of Streptococcus Suis to Penicillin [PDF]

Journal of Veterinary Diagnostic Investigation, 1991
The main objective of this study was to determine the minimal inhibitory concentrations (MICs) of penicillin for representative strains of all known capsular types of S. suis. Because the blood supplement for the media in different laboratories may have varied, sheep blood and bovine blood were used to study the effect of different media on bacterial ...
M, Gottschalk, P, Turgeon, R, Higgins, M, Beaudoin, A M, Bourgault   +4 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PK-PD Integration Modeling and Cutoff Value of Florfenicol against Streptococcus suis in Pigs

Frontiers in Pharmacology, 2018
The aims of the present study were to establish optimal doses and provide an alternate COPD for florfenicol against Streptococcus suis based on pharmacokinetic-pharmacodynamic integration modeling.
Zhixin Lei, Zhixin Lei, Zhixin Lei, Qianying Liu, Qianying Liu, Shuaike Yang, Shuaike Yang, Bing Yang, Bing Yang, Haseeb Khaliq, Kun Li, Kun Li, Saeed Ahmed, Saeed Ahmed, Abdul Sajid, Abdul Sajid, Bingzhou Zhang, Pin Chen, Pin Chen, Yinsheng Qiu, Jiyue Cao, Jiyue Cao, Qigai He   +22 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source