Results 61 to 70 of about 158,966 (261)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen

BMC Genomics, 2022
Streptococcus parasuis (S. parasuis) is a close relative of Streptococcus suis (S. suis), composed of former members of S. suis serotypes 20, 22 and 26. S.
Genglin Guo, Zhuohao Wang, Quan Li, Yanfei Yu, Yubao Li, Zhongming Tan, Wei Zhang   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Population structure of Australian isolates of Streptococcus suis [PDF]

, 1993
The genetic diversity of 109 isolates of Streptococcus suis, which were recovered mainly from Australian pigs, was examined by multilocus enzyme electrophoresis. The collection was genetically diverse.
Robertson, I.D., Hampson, D.J., Clarke, I.L., Trott, D.J., Mwaniki, C.G.   +4 more
core  

Streptococcus suis pathogenesis—A diverse array of virulence factors for a zoonotic lifestyle

, 2021
Streptococcus suis is a major cause of respiratory tract and invasive infections in pigs and is responsible for a substantial disease burden in the pig industry. S. suis is also a significant cause of bacterial meningitis in humans, particularly in South
Atack, JM, Patrick J. Blackall, Tram, G, Michael P. Jennings, John M. Atack, Greg Tram, Jennings, MP, Blackall, PJ   +7 more
core   +1 more source

Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota [PDF]

, 2020
Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S.
Correa-Fiz, Florencia, Martinez, Blanca, Neila-Ibáñez, Carlos, López-Soria, Sergio, Neila-Ibáñez, Carlos María, Napp Avelli, Sebastián, Napp, Sebastian, Migura-Garcia, Lourdes, Tibble, Simon, Aragon, Virginia, Sobrevia, Laia   +10 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

KARAKTERISASI FENOTIPE Streptococcus suis = THE PHENOTYPE CHARACTERIZATION OF Streptococcus suis [PDF]

, 2001
Streptococcus suis telah diketahui menyebabkan meningitis, artritis dan septikemia pada babi, manusia dan hewanhewan lain. Penelitian ini bertujuan untuk mengetahui sifat fenotipe Streptococcus sins rneliputi sifat pertumbuhannyi dalam media cair, media ...
Khusnani, Siti Isrina Oktavia Salasia
core   +3 more sources

Streptococcus suis Serotype 2 Capsule In Vivo

Emerging Infectious Diseases, 2016
Many Streptococcus suis isolates from porcine endocarditis in slaughterhouses have lost their capsule and are considered avirulent. However, we retrieved capsule- and virulence-recovered S. suis after in vivo passages of a nonencapsulated strain in mice,
Jean-Philippe Auger, Nattakan Meekhanon, Masatoshi Okura, Makoto Osaki, Marcelo Gottschalk, Tsutomu Sekizaki, Daisuke Takamatsu   +6 more
doaj   +1 more source

Case of Streptococcus suis meningitis in a French cooker and review [PDF]

Journal of Microbiology and Infectious Diseases, 2016
Streptococcus suis is an emerging zoonotic pathogen, increasingly reported worldwide and especially in Asia. S. suis remains rare in France but is responsible for outbreaks in Asia, causing meningitis, septicemia, endocarditis, arthritis and septic ...
Astrid Malézieux-Picard, Anne De monte, Nicolas Degand
doaj   +1 more source