Results 21 to 30 of about 1,082 (135)
Protein Activation of Streptolysin ‘O’ [PDF]
Nature, 1950 MANY studies have been made of streptococcal haemolysins. Todd1 demonstrated essential differences between the ‘O’ and ‘S’ forms of streptolysin. Herbert and Todd2 made a more exhaustive study of streptolysin ‘O’ and characterized it as a protein capable of haemolysing red cells, only, however, after activation with —SH-containing reducing agents.
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Redox‐aktivierte Sonden für Hochkontrastige Live‐Bildgebung Postsynaptischer Neuronaler Gerüste
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.Sylives sind modifizierte fluoreszierende Peptide für eine kontrastreiche Live‐Bildgebung inhibitorischer (Gephyrin) und exzitatorischer (PSD‐95) postsynaptischer Gerüststrukturen in nativen Neuronen. Eine saubere Markierung erfordert niedrige Sondenkonzentrationen im Nanomolarbereich, während die Aufnahme mikromolare Konzentrationen zellpenetrierender
Christiane Huhn +10 more
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Redox‐Activated Probes Enable High‐Contrast Live Imaging of Native Postsynaptic Scaffolds
Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.Sylives are modified fluorescent peptides for high‐contrast live imaging of inhibitory (gephyrin) and excitatory (PSD‐95) postsynaptic scaffolds in native neurons. Clean labeling requires low nanomolar probe levels, whereas uptake needs micromolar cell‐penetrating peptide (CPP).
Christiane Huhn +10 more
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Streptolysin S activation by lipoteichoic acid [PDF]
Infection and Immunity, 1981 Lipoteichoic acid from streptococci and Staphylococcus aureus both activated membrane-bound precursor streptolysin S and induced the formation of extracellular streptolysin S. Lipoteichoic acid could replace other substances, such as yeast ribonucleic acid core, that act as carriers for hemolysin but which are not components of the streptococcus or the
T S, Theodore, G B, Calandra
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Pediatric Non‐Lupus Full House Nephropathy: Case Report and Review of Literature
Clinical Case Reports, Volume 14, Issue 3, March 2026.ABSTRACT Lupus nephritis is a severe manifestation of systemic lupus erythematosus (SLE) typically characterized by glomerular “full‐house” immunofluorescence. However, non‐lupus nephropathies may occasionally exhibit similar patterns, creating diagnostic uncertainty.
Mohammad Firoz Anjum +4 more
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Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, Volume 293, Issue 5, Page 1285-1296, March 2026.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
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Mechanism of membrane damage by streptolysin-O [PDF]
Infection and Immunity, 1985 Streptolysin-O (SLO) is a thiol-activated, membrane-damaging protein toxin of Mr 69,000 that is produced by most strains of beta-hemolytic group A streptococci. Native, primarily water-soluble toxin molecules bind to cholesterol-containing target membranes to assemble into supramolecular curved rod structures (25 to 100 nm long by ca.
S, Bhakdi +2 more
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Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
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Rifampin: The Cause of Acute Tubular Injury—A Case Report
Case Reports in Nephrology, Volume 2026, Issue 1, 2026.Tuberculosis (TB) presents with fever, night sweats, and cough. The antituberculous therapy (ATT) used to treat TB affects various systems, including the renal system and the hepatobiliary system. ATT‐induced acute tubular necrosis (ATN) can have various presentations, such as fever, vomiting, diarrhea, abdominal pain, oliguria, and cola‐colored urine.
Muhammad Umer Arif +5 more
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Narcolepsy Associated With Streptococcal Infection: A Case Report and Literature Review
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Streptococcal infection–induced narcolepsy is a rare neurological disorder that may be accompanied by severe psychiatric symptoms and social dysfunction. In this case, delayed diagnosis and treatment were followed by progressive symptom worsening, including marked cognitive decline.
Zhenzhen Zhu +5 more
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