Targeted Regulation of Protein Expression in Vibrio parahaemolyticus [PDF]
BiologyV. parahaemolyticus has several virulence factors, including thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), and two separate type III secretion systems (T3SSs), T3SS1 and T3SS2.
Takashi Uebanso +7 more
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Disruption of Functional Membrane Microdomains Enhances Methicillin-Resistant Staphylococcus aureus Pathogenesis via Hyperexpression of Hemolysins [PDF]
Veterinary Sciences(1) Background: methicillin‑resistant Staphylococcus aureus (MRSA) is a zoonotic pathogen, and its hemolysins serve as key virulence factors. Functional membrane microdomains (FMMs) are protein-enriching platforms and regulate diverse physiological ...
Bingtian Jin +7 more
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Frontiers in Veterinary Science, 2021 We evaluated the efficacy of three vaccine formulations containing different combinations of proteins (43K OMP, leukotoxin recombinant protein PL4 and hemolysin recombinant protein H2) and killed whole cell Fusobacterium necrophorum in preventing liver ...
Jiawei Xiao +7 more
doaj +3 more sources
Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis [PDF]
BMC MicrobiologyThe availability of nutrients is closely linked to the protein expression profile of microorganisms. In this study, a comparative investigation has been performed to examine the expression patterns of cell associated proteins and secreted proteins in ...
Wanting Zhu +9 more
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Identification of two neutralizing human single-chain variable fragment antibodies targeting Staphylococcus aureus alpha-hemolysin [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): The inability of the host immune system to defeat Staphylococcus aureus is due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins, which interrupt the function of immune components.
Somayeh Piri-Gavgani +5 more
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Use of black soldier fly (Hermetia illucens) prepupae amino acids as anti Aeromonas hydrophila enterotoxin in vivo [PDF]
Iraqi Journal of Veterinary Sciences, 2023 Aeromonas hydrophila is an opportunistic freshwater. These bacteria cause gastroenteritis and septicemia in animals and humans. Hemolysin and aerolysin, are important in the pathogenesis of A. hydrophila.
Dahliatul Qosimah +5 more
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RNase A does not translocate the alpha-hemolysin pore. [PDF]
PLoS ONE, 2014 The application of nanopore sensing utilizing the α-hemolysin pore to probe proteins at single-molecule resolution has expanded rapidly. In some studies protein translocation through the α-hemolysin has been reported. However, there is no direct evidence,
Besnik Krasniqi, Jeremy S Lee
doaj +1 more source
Frontiers in Veterinary Science, 2021 Edwardsiella ictaluri is a Gram-negative facultative intracellular pathogen causing enteric septicemia of catfish (ESC), a devastating disease resulting in significant economic losses in the U.S. catfish industry. Bacterial secretion systems are involved
Safak Kalindamar +4 more
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IL-21 Enhances the Immune Protection Induced by the Vibrio vulnificus Hemolysin A Protein [PDF]
Inflammation, 2021 Abstract We previously reported that the Vibrio vulnificus hemolysin A (VvhA) protein elicited good immune protection and could effectively control V. vulnificus infection in mice. However, its molecular mechanism remains unknown. In this study, we found that IL-21 enhances immune protection by inducing a Tfh-cell and germinal center (GC) B ...
Ke-Na Sun +5 more
openaire +3 more sources
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. [PDF]
PLoS ONE, 2009 Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) causes severe necrotizing infections of the skin, soft tissues, and lungs. Staphylococcal alpha-hemolysin is an essential virulence factor in mouse models of CA-MRSA necrotizing ...
Robin R Craven +7 more
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