Characterization of the Xiamenmycin Biosynthesis Gene Cluster in Streptomyces xiamenensis 318 [PDF]
PLoS ONE, 2014 Xiamenmycin (1) is a prenylated benzopyran derivative with anti-fibrotic activity. To investigate the genetic basis of xiamenmycin biosynthesis, we performed genome mining in the xiamenmycin-producing Streptomyces xiamenensis wild-type strain 318 to ...
Min-Juan Xu, Jun Xu
exaly +8 more sources
Identification of Two Novel Anti-Fibrotic Benzopyran Compounds Produced by Engineered Strains Derived from Streptomyces xiamenensis M1-94P that Originated from Deep-Sea Sediments [PDF]
Marine Drugs, 2013 The benzopyran compound obtained by cultivating a mangrove-derived strain, Streptomyces xiamenensis strain 318, shows multiple biological effects, including anti-fibrotic and anti-hypertrophic scar properties.
Zhi-Gang Zhang, Min-Juan Xu, Jun Xu
exaly +8 more sources
Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis [PDF]
Marine Drugs, 2012 An anti-fibrotic compound produced by Streptomyces xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis.
Min-Juan Xu, Ping Ao, Wen-Han Lin
exaly +9 more sources
Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318 [PDF]
Royal Society Open Science, 2019 The production of secondary metabolites, while important for bioengineering purposes, presents a paradox in itself. Though widely existing in plants and bacteria, they have no definite physiological roles.
Xiao-Mei Zhu +9 more
doaj +5 more sources
A Novel AdpA Homologue Negatively Regulates Morphological Differentiation in Streptomyces xiamenensis 318 [PDF]
Applied and Environmental Microbiology, 2019 AdpA is a key regulator of secondary metabolism and morphological differentiation inStreptomycesspecies. However, AdpA had not been reported to negatively regulate morphological differentiation. Here, we characterized the regulatory role of AdpASxinStreptomyces xiamenensis318, which has a naturally streamlined genome.
Min-Juan Xu, Jun Xu
exaly +6 more sources
Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin [PDF]
Scientific Reports, 2016 AbstractStreptomyces xiamenensis 318, a moderate halophile isolated from a mangrove sediment, produces the anti-fibrotic compound xiamenmycin. The whole genome sequence of strain 318 was obtained through long-read single-molecule real-time (SMRT) sequencing, high-throughput Illumina HiSeq and 454 pyrosequencing technologies.
Min-Juan Xu, Hong-Yu Ou, Ping Ao
exaly +6 more sources
Chlokamycins B–D: Chlorohydrin-Containing Polycyclic Tetramate Macrolactams with Cytotoxic Activity from the Marine Sponge-Derived Streptomyces xiamenensis 1310KO-148 [PDF]
Marine DrugsChemical investigation of the marine sponge-derived Streptomyces xiamenensis 1310KO-148 afforded six polycyclic tetramate macrolactams (PTMs), including three known compounds (1–3) and three previously undescribed chlorohydrin-containing analogues ...
Min Ah Lee +6 more
doaj +5 more sources
Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase [PDF]
Scientific Reports, 2017 AbstractPolycyclic tetramate macrolactams (PTMs) were identified as distinct secondary metabolites of the mangrove-derived Streptomyces xiamenensis 318. Together with three known compounds—ikarugamycin (1), capsimycin (2) and capsimycin B (3)—two new compounds, capsimycin C (4) with trans-diols and capsimycin D (5) with trans-configurations at C-13/C ...
Xiao-Mei Yang +2 more
exaly +6 more sources
Correction to: ‘Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318’ [PDF]
Royal Society Open Science, 2019 Xiao-Mei Zhu +9 more
doaj +4 more sources
Genomes of four Streptomyces strains reveal insights into putative new species and pathogenicity of scab-causing organisms [PDF]
BMC Genomics, 2023 Genomes of four Streptomyces isolates, two putative new species (Streptomyces sp. JH14 and Streptomyces sp. JH34) and two non thaxtomin-producing pathogens (Streptomyces sp. JH002 and Streptomyces sp.
Laura Henao +4 more
doaj +2 more sources