Results 161 to 170 of about 13,379 (221)

Streptozocin–Doxorubicin, Streptozocin–Fluorouracil, or Chlorozotocin in the Treatment of Advanced Islet-Cell Carcinoma

New England Journal of Medicine, 1992
The combination of streptozocin and fluorouracil has become the standard therapy for advanced islet-cell carcinoma. However, doxorubicin has also been shown to be active against this type of tumor, as has chlorozotocin, a drug that is structurally similar to streptozocin but less frequently causes vomiting.In this multicenter trial, we randomly ...
Stuart R Lipsitz
exaly   +3 more sources

Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma

New England Journal of Medicine, 1980
To evaluate the treatment of advanced islet-cell carcinoma, we randomly assigned 84 patients to streptozocin alone or streptozocin plus fluorouracil. Each regimen was given in five-day courses. The most frequent toxic effects were nausea and vomiting, mild and reversible renal toxicity, and bone-marrow depression with the combination regimen.
C G, Moertel, J A, Hanley, L A, Johnson
exaly   +3 more sources

Streptozocin-induced diabetes mellitus in the pregnant ewe

American Journal of Obstetrics and Gynecology, 1991
To evaluate the effects of streptozocin on maternal pancreatic beta-cell function, we administered the agent to 14 pregnant ewes at 85 to 90 days' gestation on two occasions, 4 days apart. Intravenous glucose tolerance tests were performed before the initial administration, before the second dose, and 4 weeks after the final dose of streptozocin. There
Jan E Dickinson
exaly   +3 more sources

Definition of Streptozocin Toxicity for Primary Lymphoidal Tissues

Diabetes, 1986
Hyperglycemia was induced in BALB/c mice with either streptozocin or alloxan to evaluate the effects of these drugs on primary lymphoidal tissues. Streptozocin but not alloxan 1) briefly inhibited in situ DNA synthesis in bone marrow and thymus, 2) elicited a transient selective depletion of circulating lymphocytes, and 3) elicited a transient ...
exaly   +3 more sources

Acute Febrile Reaction to Streptozocin

New England Journal of Medicine, 1984
exaly   +2 more sources

Nephrotoxicity of Streptozocin

Annals of Internal Medicine, 1982
Excerpt To the editor: Streptozocin has known nephrotoxicity. Reported cases have documented development of hypophosphatemia as the earliest finding followed by glycosuria, proteinuria, and finally...
DAVID J. PERRY, RAYMOND B. WEISS
openaire   +1 more source

Preliminary model for streptozocin metabolism in mice

Journal of Pharmaceutical Sciences, 1980
A mathematical model for streptozocin metabolism in mice is presented. By using the available bioassay and chemical assay data for a 300-mg/kg ip injection and the principles of physiologically based pharmacokinetics, a membrane-limited transport model with first-order kinetics was found to simulate the data adequately (average error of less than 20%).
J M, Weissbrod, R K, Jain
openaire   +2 more sources

Hazards of Hepatic Artery Infusion of Streptozocin

Scottish Medical Journal, 1979
Three patients with metastatic malignancy received streptozocin by hepatic artery infusion through a percutaneous transfemoral catheter. Two patients developed major arterial thrombosis, from which one died. The other suffered renal damage following displacement of the catheter tip. Possible avoidable risk factors are identified.
S, Holt, A, Naysmith, J, Reid, T A, Buist   +3 more
openaire   +2 more sources

Calcein Fluorophotometry in Streptozocin-Induced Diabetic Rats

Ophthalmic Surgery, Lasers and Imaging Retina, 1994
ABSTRACT Calcein was used in vitreous flu oro photometry (VF) to study the blood-retinal barrier (BRB) in rats with streptozocin-induced diabetes. Calcein was injected intravenously in 18 diabetic rats and sodium fluorescein (NaF) in 12 diabetic rats.
M R, Golshani, B, Khoobehi, G A, Peyman, C, Aras   +3 more
openaire   +2 more sources