PLAGL1 overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual DNA damage and cGAS/STING pathway activation [PDF]
Journal of Diabetes InvestigationBackground Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood ...
Cheng Li +6 more
doaj +3 more sources
New Insight on Insulinoma Treatment in a Pet Rat—A Case Report
Animals, 2022 Insulinomas are insulin-producing tumors of pancreatic beta cells that cause hypoglycemia. They are extremely common in ferrets but have also been reported in guinea pigs and rats.
Agata Godlewska +3 more
doaj +1 more source
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. [PDF]
PLoS Biology, 2007 Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse
Yi-Chieh Nancy Du +3 more
doaj +1 more source
Serous Microcystic Adenoma of Pancreas: A Case Series from a Tertiary Care Centre in Southern India [PDF]
Journal of Clinical and Diagnostic Research, 2017 Serous microcystic adenoma is a rare exocrine tumour of the cystic neoplasm of pancreas seen predominantly in the elderly population. The first patient was a 56-year-old diabetic woman with abdominal pain, constipation and loss of weight since two ...
K Rajasree Varma +3 more
doaj +1 more source
Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron-specific enolase and the alpha-subunit of glycoprotein hormones [PDF]
, 1997 Chromogranin A (CgA) is gaining acceptance as a serum marker of neuroendocrine tumors. Its specificity in differentiating between neuroendocrine and nonneuroendocrine tumors, its sensitivity to detect small tumors, and its clinical ...
Bouillon, R. (Roger) +8 more
core +11 more sources
Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter [PDF]
, 2015 Naturally occurring diabetes mellitus (DM) is common in domestic cats (Felis catus). It has been proposed as a model for human Type 2 DM given many shared features.
AC Dirtu +44 more
core +8 more sources
NEONATAL ISLET CELL ADENOMA [PDF]
Pediatric Research, 1977 In each of 8 cases of neonatal islet cell adenoma, pregnancy labor, delivery and birth weight were normal. Seizures began at 5 hours in 1 case, 24-48 hours in 4 cases and 6 and 7 weeks in 2 cases; in late onset cases, fasting symptoms were overlooked for weeks.
Larry C Deeb, Robert A Ulstrom
openaire +1 more source
An interesting case of malignant paraganglioma of the mandible with calvarial metastasis
Journal of Indian Academy of Oral Medicine and Radiology, 2018 Paraganglioma is a rare neuroendocrine tumor arising from the neuroectodermally derived paraganglionic cells scattered throughout the body. Other neuroendocrine tumors include carcinoids, islet cell tumors, medullary carcinoma of thyroid, melanoma ...
Ravi Prakash Sasankoti Mohan +3 more
doaj +1 more source
Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion [PDF]
, 1989 We investigated the molecular size of circulating immunoreactive ACTH by gel chromatography in patients with ACTH hypersecretion due to various disorders of the hypothalamic-pituitary-adrenal axis.
A Chatelain +19 more
core +1 more source
Hypoglycaemic crisis induced by non-islet cell tumours in two dogs
Veterinární Medicína, 2019 Two dogs were admitted for the diagnosis and treatment of neoplasia (a hepatic and a mammary tumour, respectively), lethargy, quadriparesis and abnormal mentation with hypoglycaemia.
Hakhyun Kim +3 more
doaj +1 more source