PLAGL1 overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual DNA damage and cGAS/STING pathway activation [PDF]
Journal of Diabetes InvestigationBackground Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood ...
Cheng Li +6 more
doaj +3 more sources
Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues. [PDF]
Physiol RepMechanisms of autocrine orexinergic effects in extra‐hypothalamic tissues. Abstract Orexin‐A and orexin‐B, originally discovered as hypothalamic neuropeptides, have been detected in extra‐hypothalamic tissues together with their receptors (OX1R and OX2R) since the early 2000s.
Hakizimana JC, Olubiyi MV, Alagbonsi AI.
europepmc +2 more sources
New Insight on Insulinoma Treatment in a Pet Rat—A Case Report
Animals, 2022 Insulinomas are insulin-producing tumors of pancreatic beta cells that cause hypoglycemia. They are extremely common in ferrets but have also been reported in guinea pigs and rats.
Agata Godlewska +3 more
doaj +1 more source
CT and MRI Manifestations of Pancreatic Hemangioma: A Literature Review and a New Case Report. [PDF]
Clin Case RepABSTRACT Pancreatic hemangioma is an extremely rare benign tumor occurring in the pancreas. Preoperative diagnosis is challenging due to its lack of specificity in clinical manifestations and imaging examinations. A pancreatic lesion was found during physical examination of a 54‐year‐old woman who had no symptoms of abdominal discomfort.
Zhang J, Chen J, Zou D, Cao X.
europepmc +2 more sources
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. [PDF]
PLoS Biology, 2007 Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse
Yi-Chieh Nancy Du +3 more
doaj +1 more source
Serous Microcystic Adenoma of Pancreas: A Case Series from a Tertiary Care Centre in Southern India [PDF]
Journal of Clinical and Diagnostic Research, 2017 Serous microcystic adenoma is a rare exocrine tumour of the cystic neoplasm of pancreas seen predominantly in the elderly population. The first patient was a 56-year-old diabetic woman with abdominal pain, constipation and loss of weight since two ...
K Rajasree Varma +3 more
doaj +1 more source
Unveiling the Invisible: A Case of Canine Diffuse Microscopic Pancreatic Adenocarcinoma With Normal Imaging and Gross Appearance of the Pancreas Complicated by Sterile Peritonitis and Disseminated Intravascular Coagulation. [PDF]
Vet Med SciThis case report describes an atypical presentation of diffuse microscopic pancreatic adenocarcinoma in an 11‐year‐old male neutered Shetland Sheepdog, which was not detectable on advanced diagnostic imaging or during exploratory laparotomy. Despite the absence of visible pancreatic abnormalities, histopathology confirmed malignant infiltration ...
Chan HM +7 more
europepmc +2 more sources
An Often Missed Cause of Chronic Pancreatitis: A Case Report on the Rare Presentation of Primary Hyperparathyroidism. [PDF]
Clin Case RepABSTRACT A 30‐year‐old woman with recurrent pancreatitis and nephrolithiasis was diagnosed with chronic calcific pancreatitis linked to primary hyperparathyroidism (PHPT). Following decompression of the pancreas and parathyroidectomy, her symptoms resolved and PTH levels normalized.
Ibraheem K +5 more
europepmc +2 more sources
NEONATAL ISLET CELL ADENOMA [PDF]
Pediatric Research, 1977 In each of 8 cases of neonatal islet cell adenoma, pregnancy labor, delivery and birth weight were normal. Seizures began at 5 hours in 1 case, 24-48 hours in 4 cases and 6 and 7 weeks in 2 cases; in late onset cases, fasting symptoms were overlooked for weeks.
Larry C Deeb, Robert A Ulstrom
openaire +1 more source
An interesting case of malignant paraganglioma of the mandible with calvarial metastasis
Journal of Indian Academy of Oral Medicine and Radiology, 2018 Paraganglioma is a rare neuroendocrine tumor arising from the neuroectodermally derived paraganglionic cells scattered throughout the body. Other neuroendocrine tumors include carcinoids, islet cell tumors, medullary carcinoma of thyroid, melanoma ...
Ravi Prakash Sasankoti Mohan +3 more
doaj +1 more source