Results 61 to 70 of about 248,063 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Strain gradient effects on concrete stress-strain curve [PDF]

, 2012
The stress–strain characteristic of concrete developed in flexure is one of the essential parameters for the ultimate flexural strength design of reinforced concrete (RC) members.
Peng, J, Ho, JCM
core   +1 more source

Evaluation of Mechanical Parameters of Pellets

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
The paper dealt with the evaluation of mechanical properties of the cylinder wheat straw, rapeseed straw and 50/50 % mixed wheat and rapeseed straw pellet samples. The pellets were made by the granulating machine MGL 200 (Kovonovak).
Ľubomír Kubík, František Adamovský, Viera Kažimírová   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Plasticity and Time: Using the Stress-Strain Curve as a Framework for Investigating the Wicked Problems of Marine Pollution and Climate Change [PDF]

Plastics have become the characteristic material of the current Plastic Age. Yet plastics are also a highly contested form of heritage. Intact and functioning, they are useful, but when compromised they lose their utility and often also their heritage ...
Schofield, John,, Pocock, Celmara
core   +1 more source

Proposed Model for Uniaxial Tensile Behavior of Ultra High Performance Concrete [PDF]

Engineering and Technology Journal, 2015
This paper investigates experimentally the complete uniaxial tensile stress-strain relationships of Ultra High Performance Concrete (UHPC) and equations for expressing such relationships are obtained.
Hisham M. Al-Hassani, Wasan I. Khalil, Lubna S. Danha   +2 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Study on Constitutive Relation of Concrete under Sulfate Attack and Freeze-Thaw Environment

工程科学与技术, 2016
:In order to study the stress-strain relationship of concrete under sulfate attack and freeze-thaw cycles, the uniaxial compression experiments of concrete subjected to freeze-thaw cycles in water, and mass fraction of 5% sodium sulfate, 5% magnesium ...
Jiang Lei
doaj  

Dynamic constitutive model of Fe–Cr–Ni stainless steel based on isothermal true stress-strain curves

Journal of Materials Research and Technology
Austenitic Fe–Cr–Ni stainless steel is widely used in aviation, chemistry, energy, due to its excellent properties of high-temperature performance. In this study, the splitting Hopkinson pressure bar with high-temperature system was employed to evaluate ...
Chenchong Du, Feng Jiang, Bicheng Guo, Yong Zhang   +3 more
doaj   +1 more source