Results 71 to 80 of about 248,063 (265)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Triaxial compression stress-strain curve for the sealing material.

open access: yes, 2023
Triaxial compression stress-strain curve for the sealing material.
Lei Xu (78676)   +3 more
core   +1 more source

A Stress-Strain Model for Brick Prism under Uniaxial Compression

open access: yesAdvances in Civil Engineering, 2019
This study proposes a simple and rational stress-strain relationship model applicable to brick masonry under compression. The brick prism compression tests were conducted with different mortar strengths and with constant brick strength.
Keun-Hyeok Yang   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Stress-strain curve of HVA with linear amplitude scanning test.

open access: yes
Stress-strain curve of HVA with linear amplitude scanning test.
Fujing Zhao (17827355)   +5 more
core   +1 more source

Uniaxial stress-strain curve for steel.

open access: yes, 2016
Uniaxial stress-strain curve for steel.
M. M. Tahir (2901188)   +4 more
core   +1 more source

Research on axial compressive performance of ceramic concrete reinforced with HTPP fibers

open access: yesCase Studies in Construction Materials
This study investigates the influence of High-Toughness Polypropylene (HTPP) fiber content (0 %, 0.3 %, 0.6 %, 0.9 %) on the axial compressive performance of ceramsite concrete.
Hongjian Lin   +11 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

A Simple and Efficient Method for Obtaining the Whole-Range Uniaxial Tensile Properties of Pipeline Steel

open access: yesMetals, 2018
To obtain the whole-range true stress-true strain curves of API X65, a method is proposed based on the equal proportion principle and digital images. The tensile elongation was obtained by tracing the gauge points on the specimen surface, and the true ...
Lingzhen Kong   +5 more
doaj   +1 more source

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