Results 111 to 120 of about 31,042,989 (282)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

STRESS AND STRAIN STATE OF REPAIRING SECTION OF PIPELINE

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2015
Reliability of continuous operation of pipelines is an actual problem. For this reason should be developed an effective warning system of the main pipelines‘  failures and accidents not only in design and operation but also in selected repair.
V. V. Nikolaev
doaj  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Investigation of the Stress-Strain State of a Wheel Flange of the Locomotive by the Method of Finite Element Modeling

, 2018
The rail mode of transport has become the main transit of goods in States with no direct outlets to the world ocean In connection with their health and the necessary technical support key moment in the economic development of the state.
K. Zhussupov, Aliya Toktamyssova, S. Abdullayev, G. Bakyt, M. Yessengaliyev   +4 more
semanticscholar   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Theoretical and experimental studies of the stress–strain state of expansion bellows as elastic shells ☆

, 2017
This paper studies the stress–strain state of an U-shaped expansion bellows under an internal-pressure induced load. The bellows is considered as a corrugated shell of revolution under axisymmetric load.
A. K. Belyaev, T. V. Zinovieva, K. Smirnov   +2 more
semanticscholar   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

THE STRAIN- STRESS STATE OF STEEL REINFORCED CONCRETE BEAMS

Nauka ta progres transportu, 2010
The experimental investigations of steel-reinforced concrete beams composed of double-T No. 16 and the reinforced concrete slab of size 220×60×1200 mm were conducted.
A. V. Krukhmalov
doaj  

NUMERICAL ANALYSIS OF THE STRESS-STRAIN STATE OF A ROPE STRAND WITH LINEAR CONTACT UNDER TENSION AND TORSION LOADING CONDITIONS

, 2017
The paper presents the results of a numerical analysis of the stress-strain state of a rope strand with linear contact under tension and torsion loading conditions. Calculations are carried out using the ANSYS software package.
E. Kalentev, Š. Václav, P. Božek, A. Korshunov, V. Tarasov   +4 more
semanticscholar   +1 more source