Results 101 to 110 of about 31,042,989 (282)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Study of stress-strain state of the roller conveyor

Metalurgija, 2022
Numerous studies have established that the damage to the lower surface of hot-rolled strips is mainly due to their friction against rollers of mill rollers. In this case, the probability of scoring, scrapes and other mechanical damage increases otherwise
D. Yergaliyev, A. Tulegulov, A. Zhumabayeva, A. Bukayeva, M. Suimenova, G. Yesbolay, A. Yussupov, A. Zhauyt   +7 more
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

On the stress update algorithm of an advanced critical state elasto-plastic model and the effect of yield function equation [PDF]

, 2014
This paper investigates the computational performance of S-CLAY1S constitutive model by varying its yield function equation. S-CLAY1S is an advanced anisotropic elasto-plastic model that has been developed based on the extension of conventional critical ...
Rezania, Mohammad, Sivasithamparam, Nallathamby, Mousavi Nezhad, Mohaddeseh   +2 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

An experimental method to measure dynamic stress-strain relationship of materials at high strain rates

, 2014
In this paper, an experimental method for measuring dynamic behavior of materials at high strain rates is developed. The strain and stress of a specimen are obtained using a high-precision photonic Doppler velocimetry system and a sensitive ...
Huang, CG (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China., 王曦, 黄晨光, 宋宏伟, 魏延鹏, 吴先前   +5 more
core   +1 more source

SOLUTION OF ANTI-SYMMETRIC THERMO-ELASTIC PROBLEM FOR NON-UNIFORMLY HEATED LONG CYLINDER UNDER CREEPING CONDITIONS

Наука и техника, 2009
The paper investigates anti-symmetric stress-strain state of  infinitely long solid cylinder subjected to irregular heating, external pressure under conditions of thermal creeping.
I. S. Kulikov, P. I. Shirvel
doaj  

Investigation of the rock mass state in the near-wall part of the quarry and its stability management

Frontiers in Earth Science
Introduction: The research is aimed to identify the vulnerable areas of quarry slopes through the creation of a stress-strain state model for the rock mass at the Vostochny quarry, East Saryoba field of the Zhi-landy Group of cupriferous sandstones, as ...
Pavlo Saik, Kanay Rysbekov, Khaini-Kamal Kassymkanova, Vasyl Lozynskyi, Vasyl Lozynskyi, Guldana Kyrgizbayeva, Serik Moldabayev, Dmytro Babets, Arnat Salkynov   +8 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source