Results 31 to 40 of about 697,108 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in Earth Science, 2020 Using the cyclic loading and unloading method, rheological tests of intact sandstones and composite sandstones containing a weak interlayer (WI) with inclination angles 15°, 30°, 45°, and 60° under different axial loading were carried out.
Liming Tang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2014 In this paper, an experimental method for measuring dynamic behavior of materials at high strain rates is developed. The strain and stress of a specimen are obtained using a high-precision photonic Doppler velocimetry system and a sensitive ...
Huang, CG (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China. +5 more
core +1 more source
Variation of the stress-and-strain state of the Vuoksi Fault Zone area (Vyborg district)
, 2021 The stress-and-strain state of the rock massif and the kinematic type of faults of the Vuoksi fault zone (Karelian Isthmus) for the latest stage of tectonic history were determined by field tectonophysical methods.
Bondar, Ivan V. +2 more
core +1 more source
InfrastructuresThis article presents the fundamentals of an analytical method for determining the stress–strain state of a railway subgrade reinforced with geosynthetic material.
Ahmad Alkhdour +3 more
doaj +1 more source
Bone Stress-Strain State Evaluation Using CT Based FEM
Frontiers in Mechanical Engineering, 2021 Nowadays, the use of a digital prototype in numerical modeling is one of the main approaches to calculating the elements of an inhomogeneous structure under the influence of external forces. The article considers a finite element analysis method based on
Oleg V. Gerasimov +9 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source