Results 61 to 70 of about 536,508 (263)

A Discrete Fracture Network Model With Stress-Driven Nucleation: Impact on Clustering, Connectivity, and Topology

Frontiers in Physics, 2020
The realism of Discrete Fracture Network (DFN) models relies on the spatial organization of fractures, which is not issued by purely stochastic DFN models. In this study, we introduce correlations between fractures by enhancing the genetic model (UFM) of Davy et al.
Etienne Lavoine, Etienne Lavoine, Philippe Davy, Caroline Darcel, Raymond Munier   +4 more
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior

Nature Communications
Experiencing a single severe stressor is sufficient to drive sexually dimorphic psychiatric disease development. The ventral subiculum (vSUB) emerges as a site where stress may induce sexually dimorphic adaptations due to its sex-specific organization ...
Carley N. Miller, Yuan Li, Kevin T. Beier, Jason Aoto   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Research on Structural Fatigue Life Prediction of Container Gantry Cranes Based on Digital Twin

Applied Sciences
Accurate assessment of cumulative fatigue damage in container gantry cranes under long-term cyclic loading is hindered by the inability of traditional single-model methods to capture real-time structural conditions.
Ze Zhu, Yujin Han, Feng Zhu, Jie Sun, Keming Chen, Yushuang Yan, Yadong Zhao   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Complex Fluid‐Driven Fractures Caused by Crack‐Parallel Stress

Geophysical Research Letters
Managing fluid‐driven fracture networks is crucial for subsurface resource utilization, yet the current understanding of the key controlling factors remains insufficient.
Wenfeng Li, Luke P. Frash, J. William Carey, Nathan J. Welch, Meng Meng, Hari S. Viswanathan   +5 more
doaj   +1 more source

Fault valving and pore pressure evolution in simulations of earthquake sequences and aseismic slip

Nature Communications, 2020
Coupling between fault zone fluid flow, permeability evolution, and elastic stress transfer produces fault valving and fluid-driven aseismic slip and pore pressure pulses.
Weiqiang Zhu, Kali L. Allison, Eric M. Dunham, Yuyun Yang   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source