Results 101 to 110 of about 18,273 (288)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Residual stress and distortion analysis of laser powder bed additive manufactured parts using the incremental hole drilling method and the cantilever method

Journal of Advanced Joining Processes
This study investigates residual stresses and distortion in additively manufactured 316L austenitic steel and M350 martensitic high strength steel produced by laser powder bed fusion under varying process parameters.
Moritz Käß, Stefan Weihe, Martin Werz
doaj   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Study of microstructure and mechanical properties and residual stresses of 24CrNiMo steel prepared by selective laser melting and laser melting deposition

Journal of Materials Research and Technology
Selective laser melting (SLM) and laser direct metal deposition (LMD) have shown promise in advanced manufacturing. However, limited research fabricating the same material using these methods, particularly regarding mechanical properties and residual ...
Yongsheng Zhao, Ying Wu, Dengwen Hu, Yuhua Cai, Yan Liu, Hui Chen   +5 more
doaj   +1 more source

Microstructural evolution of heat-treated 316L stainless steel using various etchants [PDF]

MATEC Web of Conferences
The rapid heating and cooling cycles inherent to laser additive manufacturing result in the accumulation of high residual stress magnitudes that may have an adverse effect on the material's mechanical properties.
Moumakwe Molebogeng, Arthur Nana K.K, Poopola Abimbola P.I, Raji Sadiq A.   +3 more
doaj   +1 more source

Early Stages of Fatigue Damage of Steels for Fusion Energetics [PDF]

, 2012
Hlavním cílem této práce bylo vysvětlit únavové chování ocelí ODS Eurofer, 14Cr ODS feritické oceli vyráběné v CEA (Commissariat a l’énergie atomique, Saclay, France) a 14Cr ODS feritické oceli vyráběné v EPFL (École Polytechnique Fédérale de Laussane ...
Kuběna, Ivo
core  

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Application of Alloy 718 in M-1 engine components [PDF]

Alloy 718 applied to components of M-1 rocket ...
Frick, V., Hunt, V., Inouye, F. T., Janser, G. R.   +3 more
core   +1 more source

Powder metallurgical materials and processes for soft magnetic applications [PDF]

, 2018
For many designers of electrical machines, the term “soft magnetic materials” automatically means laminated electrical sheet. This is unfortunate, since for many applications, particularly at low frequencies, laminated sheet is rarely the best material ...
Dougan, Mark J.
core  

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source