Results 51 to 60 of about 289,087 (265)

Study of the non-linear stress-strain behavior in Ti-Nb-Zr alloys

Materials Research, 2005
The aim of this work is to study the elastic behavior of some Ti-Nb-Zr alloys (Ti-8Nb-13Zr, Ti-13Nb-13Zr, Ti-18Nb-13Zr and Ti-41.1Nb-7.1Zr) developed to biomedical applications. These alloys were produced by arc melting under argon atmosphere.
Sergio Schneider, Sandra Giacomin Schneider, Helena Marques da Silva, Carlos de Moura Neto   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of bedding mortar with low strength and high entrained air content on the strain and failure mode of masonry prisms under compression [PDF]

REM: International Engineering Journal
Brazilian standards regarding structural masonry does not consider the effect of bedding mortar properties on the strength and failure mode of masonry. Thus, the objective of this study was to evaluate the effect of bedding mortars with low strength and ...
Isabela Naia Talhacoli, André Lübeck, Gihad Mohamad   +2 more
doaj   +1 more source

Low-cycle fatigue behavior of 4Cr5MoSiV1 hot-work die steel at 700 ℃

工程科学学报, 2020
4Cr5MoSiV1 hot-die steel exhibits excellent thermal fatigue and comprehensive mechanical properties, and it is widely used in hot forging die and hot extrusion die.
Chao ZHAO, Jin-feng HUANG, Jin ZHANG, Guo-liang XIE, Yong LIAN, De-chen LI, Min-yu MA, Zun-jun ZHANG, Wen GAO, Cheng ZHANG   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimizing Twin 4-8 Graphene for Advanced Applications through Mechanical Insights: Molecular Dynamics Approach [PDF]

Journal of Applied and Computational Mechanics
The mechanical properties of Twin 4-8 graphene nanosheets were systematically investigated using molecular dynamics simulations. This study examines the influence of size, temperature, defects, and layer number on the stress-strain behavior, Young’s ...
Hongfeng Wu, Jie Zhang
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Evaluation of Cyclic Stress–Strain and Liquefaction Behavior of Izmir Sand

Arabian Journal for Science and Engineering, 2014
This paper presents the results of a series of cyclic triaxial tests carried out on sands with different index properties. Samples from three grain-size distributions of Izmir (Turkey) sand were tested under consolidated-undrained conditions. The tests were performed under two different effective confining pressure values (100 and 200 kPa).
Eskisar, Tuğba, Karakan, Eyyüb, Altun, Selim   +2 more
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source