Results 41 to 50 of about 211,926 (263)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Scaffolds with a Tunable Nonlinear Elastic Region Using a Corrugated Design

Small Structures
Elastin is the main component of arteries and is responsible for their high‐elastic high‐strain capacity. The biomechanics of biological tissues typically display a stress–strain curve characterized by a sigmoidal shape that has an initial region with ...
Kenny A. van Kampen, Tim ten Brink, Carlos Mota, Lorenzo Moroni   +3 more
doaj   +1 more source

Strain Rate Impact into the Stress and Strain Values at Break of the PA6 GF30-Reinforced Polyamides

Applied Sciences
The study of the strain rate effects on the PA6 glass fiber-reinforced polyamide, in this specific case, PA6 GF30 (30% reinforced glass fiber), is critical due to composites widely used in automotive applications where the velocity of loading can vary ...
Adrian Marius Pascu, Nicolae Stefanoaea
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Novel deep learning approach for practical applications of indentation

Materials Today Advances, 2022
The instrumented indentation technique has been investigated to efficiently evaluate the mechanical responses of materials with few limitations on the shape and size of the specimen.
Yongju Kim, Gang Hee Gu, Peyman Asghari-Rad, Jaebum Noh, Junsuk Rho, Min Hong Seo, Hyoung Seop Kim   +6 more
doaj   +1 more source

Strain gradient effects on concrete stress–strain curve [PDF]

Proceedings of the Institution of Civil Engineers - Structures and Buildings, 2012
The stress–strain characteristic of concrete developed in flexure is one of the essential parameters for the ultimate flexural strength design of reinforced concrete (RC) members. Currently, the stress–strain curve of concrete developed in flexure is obtained by scaling down the uniaxial stress–strain curve.
Ho, JCM, Peng, J
openaire   +5 more sources

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of Mechanical Parameters of Pellets

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
The paper dealt with the evaluation of mechanical properties of the cylinder wheat straw, rapeseed straw and 50/50 % mixed wheat and rapeseed straw pellet samples. The pellets were made by the granulating machine MGL 200 (Kovonovak).
Ľubomír Kubík, František Adamovský, Viera Kažimírová   +2 more
doaj   +1 more source

Modified hydraulic bulging in acquisition of stress strain curve [PDF]

International Journal of Material Forming, 2010
From classical hydraulic bulging of a circular diaphragm, a new method of recording a stress-strain curve is derived named modified hydraulic bulging on the sphere. New method allows more accurate determination of membrane stress in the deforming material.
Grizelj, Branko, Škunca, Marko, Math, Miljenko   +2 more
openaire   +2 more sources