Results 71 to 80 of about 592,094 (302)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Proposed Model for Uniaxial Tensile Behavior of Ultra High Performance Concrete [PDF]

Engineering and Technology Journal, 2015
This paper investigates experimentally the complete uniaxial tensile stress-strain relationships of Ultra High Performance Concrete (UHPC) and equations for expressing such relationships are obtained.
Hisham M. Al-Hassani, Wasan I. Khalil, Lubna S. Danha   +2 more
doaj   +1 more source

Behaviour of steel fibre reinforced concrete under cyclic compressive loading [PDF]

, 2006
An experimental study was carried out to investigate the behaviour of steel fibre reinforced concrete under cyclic compressive loading. Cylindrical specimens containing two volume fractions (one percent and two percent) of steel fibres and plain concrete
Choubey, U. B., Shukla, Mukesh
core  

Shear jammed, fragile, and steady states in homogeneously strained granular materials

, 2019
We study the jamming phase diagram of sheared granular material using a novel Couette shear set-up with multi-ring bottom. The set-up uses small basal friction forces to apply a volume-conserving linear shear with no shear band to a granular system ...
Barés, Jonathan, Behringer, Robert P., Socolar, Joshua E. S., Zhao, Yiqiu, Zheng, Hu   +4 more
core   +3 more sources

Predicting shear strength mobilization of London clay [PDF]

, 2011
When designing geotechnical structures engineers need to assign soil parameters. Soil design parameters are often inferred through correlations with basic site investigation data.
Bolton, Malcolm, Vardanega, Paul J
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Plasticity-Induced Anisotropy in Amorphous Solids: the Bauschinger Effect

, 2010
Amorphous solids that underwent a strain in one direction such that they responded in a plastic manner `remember' that direction also when relaxed back to a state with zero mean stress.
Karmakar, Smarajit, Lerner, Edan, Procaccia, Itamar   +2 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Dynamic constitutive model of Fe–Cr–Ni stainless steel based on isothermal true stress-strain curves

Journal of Materials Research and Technology
Austenitic Fe–Cr–Ni stainless steel is widely used in aviation, chemistry, energy, due to its excellent properties of high-temperature performance. In this study, the splitting Hopkinson pressure bar with high-temperature system was employed to evaluate ...
Chenchong Du, Feng Jiang, Bicheng Guo, Yong Zhang   +3 more
doaj   +1 more source