Results 111 to 120 of about 37,313 (281)

Investigation of Model I Fracture in Tunnel Blasting Sections with Holes

open access: yesBuildings
In rock blasting for engineering applications—such as quarrying and tunnel construction—blasting is often detonated in carefully timed sequences to optimize rock fragmentation.
Ruifeng Liu, Yumei Du, Meng Li, Bang Liu
doaj   +1 more source

オンドク ノ リズム [PDF]

open access: yes, 2014
言語はリズムの型により分類され、強勢間の長さ、音節やモーラの長さがその基礎となると言われている。強弱や高さの違いにより形作られるリズムの等時性については議論が分かれるが、発話において等時性が観察されない場合でも、知覚においてそれが感知されるという説明もある。等時性を保つため、強勢リズム言語では第一ストレスの位置が移動し、もともと第二ストレスが置かれていた位置に収まるという現象がある。これは、リズムの衝突を避けるためのリズム規則と呼ばれている。実際の発話では、リズムの衝突を避け ...
TOMITA Kaoru
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Stressful times!

open access: yes, 2010
Within the last two years, the global economic crisis has prompted unprecedented change, with organizations traditionally considered as “solid”, crumbling and liquidating in front of incredulous stock brokers and global audiences (some examples include Fannie Mae, Freddie Mac and the Lehman Brother s Holding Inc.).
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

The Range and Diversity of Vocalic Systems in Asian Languages [PDF]

open access: yes, 2003
The purpose of this paper is first to present a general overview of the language families of Asia and what is presently commonly accepted as the relationships between these families.
Reid, Lawrence A.
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

An Analysis of Rhythmic Staccato-Vocalization Based on Frequency Demodulation for Laughter Detection in Conversational Meetings [PDF]

open access: yes, 2016
Human laugh is able to convey various kinds of meanings in human communications. There exists various kinds of human laugh signal, for example: vocalized laugh and non vocalized laugh.
Cernak, Milos   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

The acquisition of English L2 prosody by Italian native speakers: experimental data and pedagogical implications [PDF]

open access: yes, 2015
This paper investigates Yes-No question intonation patterns in English L2, Italian L1, and English L1. The aim is to test the hypothesis that L2 learners may show different acquisition strategies for different dimensions of intonation, and particularly ...
Busa', Maria Grazia, Stella, A.
core  

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