Results 131 to 140 of about 38,947 (304)
Relationship of speech rhythm, stuttering frequency and discourse type [PDF]
, 2013 The present study aimed to compare the speech rhythm of reading and conversation in Cantonese and investigates the relationship between stuttering frequency and speech rhythm across the two types of discourse.
Lam, Hiu-fung, Stephen, 林曉峰
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Design of Pulse Width Modulation of Intelligent Control System of Vibration Stress Relief
Gong-kuang zidonghua, 2012 The paper analyzed problems existed in realizing pulse width modulation of intelligent control system of vibration stress relief which includes short timing time of the single-chip microcomputer, method of initial value writing of the timer and low ...
WANG An-ming
doaj
Determining Shared Working Memory Systems for Rhythmic Incongruities in Music and Language using functional Near-Infrared Spectroscopy [PDF]
, 2014 Rhythmic organization of auditory information is used differently in the retention of music and spoken language. However, similar areas of the prefrontal cortex (PFC) have been implicated in the retention of unusual rhythmic patterns.
Mathews, Jackson T
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source