Results 151 to 160 of about 14,303,740 (385)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Comprehensive analysis of NAC transcription factors uncovers their roles during fiber development and stress response in cotton [PDF]

open access: gold, 2018
Heng Sun   +7 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats [PDF]

open access: gold, 2019
Jierong Luo   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

An innovative natural speed breeding technique for accelerated chickpea (Cicer arietinum L.) generation turnover

open access: yesPlant Methods
Background The slow breeding cycle presents a significant challenge in legume research and breeding. While current speed breeding (SB) methods promise faster plant turnover, they encounter space limitations and high costs. Enclosed environments risk pest
S. Gurumurthy   +8 more
doaj   +1 more source

Residual stress and distortion of rectangular and S-shaped Ti-6Al-4V parts by Directed Energy Deposition: Modelling and experimental calibration

open access: green, 2019
Xufei Lu   +8 more
openalex   +2 more sources

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly [PDF]

open access: gold, 2019
Qing Shi   +20 more
openalex   +1 more source

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