Results 51 to 60 of about 2,493,366 (261)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Finite-element modelling of frictional behaviour between oesophagus and endoscope

Biosurface and Biotribology, 2020
The endoscopy is the most direct and effective means for digestive tract diseases. Medical workers can conduct a series of manipulations with the help of endoscope, including checking, removing, stripping the diseased tissue or placing the stent.
Chengxiong Lin, Pan Ren, Wei Li, Hengyi Deng, Zhongrong Zhou   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic

Translational Psychiatry
The pandemic caused by SARS-CoV-2 impacted health systems globally, creating increased workload and mental stress upon health care workers (HCW). During the first pandemic wave (March to May 2020) in southern Germany, we investigated the impact of stress
Ingeborg Biener, Tonina T. Mueller, Jin Lin, Han Bao, Julius Steffen, Marion Hoerl, Katharina Biere, Sandra Matzel, Tobias Woehrle, Simon König, Annekathrin M. Keiler, Detlef Thieme, Oliver Keppler, Matthias Klein, Tobias Weinberger, Andreas Osterman, Kristina Adorjan, Alexander Choukér   +17 more
doaj   +1 more source

Passive Motion Splint Applied in Traumatology and Ortopaedics [PDF]

Transactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2013
This article deals with analysis of the knee continuous passive motion (CPM) splint used for rehabilitation of patients after surgeries and injuries. CPM splints are used for speeding up the treatment and restoration of the joint mobility and to stop ...
Gűnther THEISZ, Ivo VESELÝ, Karel FRYDRÝŠEK, Roman FOUSEK, Václav SLÁDEČEK, Leopold PLEVA   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development and Usability Evaluation of Inventive and Repurposable Children’s Furniture

Inventions
This study developed inventive and repurposable children’s furniture to improve functionality and extend product lifespan. Unlike typical cribs which serve a single purpose, the proposed design supports multiple functions: crib, cushioned chair ...
Zhi Yuan Phuah, Poh Kiat Ng, Chai Hua Tay, Boon Kian Lim, Kia Wai Liew, Peng Lean Chong   +5 more
doaj   +1 more source

Stress Analysis of Dental Implant Inserted in the Mandible

Journal of Mechanical Engineering, 2018
The aim of the paper is to obtain the values of dental implant stress analysis. The dental implant was inserted in the part of mandible bone. Stress analysis was carried out using the Finite Elements Method and simplified models.
Łagoda Agnieszka, Niesłony Adam
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modeling and Simulation of Material Type Effects on the Mechanical Behavior of Crankshafts in Internal Combustion Engines

Modelling
This research aims to study the mechanical behavior of the materials most commonly used in crankshaft manufacturing by designing a four-piston crankshaft, analyzing the stresses and displacements resulting from the applied load, and determining vibration
Hasan Mhd Nazha, Muhsen Adrah, Thaer Osman, Maysaa Shash, Daniel Juhre   +4 more
doaj   +1 more source