Results 81 to 90 of about 6,476,644 (264)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Stress Analysis of Reducedbeam Section Stell Moment Connection (Aisc 358-2005) [PDF]
, 2018 Earthquakeresistant building structures should be properly andappropiately designed, especyally in the planning and detailing of the beam - column connectins............
DWI SUNGKONO, KUKUH KURNIAWAN
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
BuildingsThis study aims to investigate the mechanical response of a submarine concrete pipeline under wave action in shallow waters, taking into account factors such as the compressibility of pores and the permeability of the seabed.
Haiyan Ju +5 more
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 Weld-joint has been atracting attention to assemble structures of dissimilar metals, particularly in automobile industry. However, the application of weld-joint to steel and aluminum plates is still limited due to uncertainty of the fatigue strength ...
Kosuke TAKAHASHI +6 more
doaj +1 more source
Finite Element Simulation of a Steady-State Stress Distribution in a Four Stroke Compressed Natural Gas-Direct Injection Engine Cylinder Head [PDF]
, 2006 The main aim of this work is to predict the design performance based on the stress/strain and thermal stress behaviour of cylinder head under various operating conditions.
Abdullah, S. +2 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Effects of Stress Evolution Process on the Thermal Stability of Thin Accretion Discs [PDF]
, 2011 The stress evolution process is taken into account in the linear stability analysis of standard thin accretion discs. We find that the growth rate of thermally unstable modes can decrease significantly owing to the stress delay, which may help to ...
Abramowicz +21 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Application of Topology Optimization in Design of Stem Profile in Hip Implants Using Finite Element Method [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2018 Appropriate design of stem shape is an important factor in total hip replacement. It affects the attachment of the implant to the bone and the stability of the implant.
Mohammad Reza Niroomand +1 more
doaj