Results 131 to 140 of about 2,595,495 (302)

Predicting taxonomic and functional structure of microbial communities in acid mine drainage. [PDF]

, 2016
Predicting the dynamics of community composition and functional attributes responding to environmental changes is an essential goal in community ecology but remains a major challenge, particularly in microbial ecology.
Chen, Linxing, He, Zhili, Hua, Zhengshuang, Huang, Linan, Jia, Pu, Kuang, Jialiang, Li, Jintian, Li, Shengjin, Liu, Jun, Shu, Wensheng, Zhou, Jizhong   +10 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Possible role of crustal flexure in the initial detachment of extensional allochthons [PDF]

The existence of low-angle normal faults indicates that the ratio of shear stress (TAU) to normal stress (sigma sub N) needed to cause slip on faults is substantially less than would be predicted based on experimental data. Because the tensional strength
Spencer, J. E.
core   +1 more source

Optimization-based comparison of different approaches for the automatized calculation of residual stresses and fiber orientations in arteries [PDF]

, 2019
Residual stresses and fiber orientations in arterial walls can be approximated by means of the simulation of growth and remodeling processes. In order to enable a comparison of different approaches of combined growth and remodeling in one framework, a ...
Balzani, Daniel, Zahn, Anna
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Turbulence modeling for high speed compressible flows [PDF]

Turbulence models are necessary in numerical simulations because of the impracticality of computing all scales of turbulent motion. Approximate methods, or turbulence models, are introduced to simplify and make the computations practical.
Chandra, Suresh
core   +1 more source

Finite element modelling of structural clay brick masonry subjected to axial compression [PDF]

, 2004
This Paper Presents The Numerical Verifications Of The Experimental Investigation On The Effect Of Mortar Joint Thickness On Compressive Strength Characteristics Of Axially Loaded Brick-Mortar Prisms.
Bakhteri, Jahangir, Makhtar, Ahmad Mahir, Sambasivam, Shamala   +2 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Model-Invariant Hybrid RANS-LES Computations on Unstructured Meshes [PDF]

Hybrid RANS-LES computations combine the bene ts of RANS and LES so that LES is used in regions where the accuracy of RANS deteriorates. The numerous hybrid approaches are limited by the speci cation of the LES-RANS interface, which can cause nonphysical
Sreekanth, R., Woodruff, Stephen L.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source