Results 91 to 100 of about 4,617,969 (324)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144

The American journal of case reports, 2019
Patient: Female, 19-year-old Final Diagnosis: Status epilepticus and stress induced cardiomyopathy Symptoms: Seizure Medication: — Clinical Procedure: — Specialty: Toxicology Objective: Unusual clinical course Background: Synthetic cannabinoids have a ...
Sarah Al Fawaz, Mohammad Al Deeb, James Huffman, Naji A Al Kholaif, F. Garlich, R. Chuang   +5 more
semanticscholar   +1 more source

Oxidative Stress and Inflammatory Modulation of Ca2+ Handling in Metabolic HFpEF-Related Left Atrial Cardiomyopathy

, 2020
Metabolic syndrome-mediated heart failure with preserved ejection fraction (HFpEF) is commonly accompanied by left atrial (LA) cardiomyopathy, significantly affecting morbidity and mortality.
Uwe Primessnig, Felix Hohendanner, Burkert M. Pieske, Abdul Parwani, Yan Wen, David Bode, Niklas Hegemann, Frank R. Heinzel, Leif-Hendrik Boldt   +8 more
core   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Takotsubo Cardiomyopathy Triggered by Emotional Stress From the Russia-Ukraine War

JACC: Case Reports, 2023
Stress-induced cardiomyopathy presents like acute coronary syndrome and is triggered by emotional stress or critical illness. Increased incidence has been reported during the COVID-19 pandemic and natural disasters.
Sarah Rikabi, MD, Sachin Kumar, MD, Gautam Shah, MD   +2 more
doaj   +1 more source

Mitochondrial SIRT3 Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress

Circulation: Heart Failure, 2022
Background: High doses of doxorubicin put cancer patients at risk for developing dilated cardiomyopathy. Previously, we showed that doxorubicin treatment decreases SIRT3 (sirtuin 3), the main mitochondrial deacetylase and increases protein acetylation in
M. Tomczyk, K. Cheung, B. Xiang, Nahid Tamanna, Ana L Fonseca Teixeira, P. Agarwal, S. Kereliuk, Victor Spicer, Ligen Lin, Jason R. Treberg, Q. Tong, V. Dolinsky   +11 more
semanticscholar   +1 more source

Dihydromyricetin Attenuates Diabetic Cardiomyopathy by Inhibiting Oxidative Stress, Inflammation and Necroptosis via Sirtuin 3 Activation

, 2023
Dihydromyricetin (DHY), the main flavonoid component in Ampelopsis grossedentata, has important benefits for health. The present study aimed to investigate the exact effects and possible mechanisms of DHY on diabetic cardiomyopathy (DCM).
Ruixiang Chen, Jiahai Shi, Yangyang Zheng, Yun Chen, Shuping Zhang, Guoliang Meng, Yunhui Gu, Jieru Shen   +7 more
core   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway.

European Journal of Pharmacology, 2022
Diabetic cardiomyopathy seriously affects the life quality of diabetic patients and can lead to heart failure and death in severe cases. Acacetin was reported to be an anti-oxidant and anti-inflammatory agent in several cardiovascular diseases.
Fei Song, Yijie Mao, Yu Hu, Shanshan Zhao, Ruiying Wang, Wei-yin Wu, Gui-Rong Li, Yan Wang, Gang Li   +8 more
semanticscholar   +1 more source

Stress-induced cardiomyopathy in aneurysmal subarachnoid hemorrhage

, 2017
Introduction: Neurogenic stunned myocardium is well described after aneurysmal subarachnoid hemorrhage. Stress-induced cardiomyopathy (takotsubo cardiomyopathy) is a form of neurogenic stunned myocardium which is not common after subarachnoid ...
Milos Kaludjerovic, Branko Milakovic, Mila Stosic, Dimitra Kalimanovska-Ostric, Tijana Nastasovic, Olga Petrovic, Danica Grujicic   +6 more
core   +1 more source