Results 31 to 40 of about 227,909 (262)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Formulation of the problem of topology optimization of automobile and agricultural machinery structures

Avtomobilʹnyj Transport (Harʹkov)
The demand for lightweight, durable, and efficient automobile and agricultural machinery structures requires advanced design methods. Topology optimization offers a solution by optimizing material distribution, but its application to complex structures ...
Tovt Bohdan, Leontiev Dmytro, Malyi Viktor   +2 more
doaj   +1 more source

Farmers’ perceptions of navy bean (Phaseolus vulgaris L.) production constraints, preferred traits and farming systems and their implications on bean breeding: a case study from South East Lowveld region of Zimbabwe

Journal of Ethnobiology and Ethnomedicine, 2021
Background Navy bean is an important legume crop in Zimbabwe. Although its production in Zimbabwe is limited by multiple constraints including biotic, abiotic and socio-economic, there is no documented evidence.
Bruce Mutari, Julia Sibiya, Eileen Bogweh Nchanji, Kennedy Simango, Edmore Gasura   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

COMPLEX STRENGTH-CONSTRAINED TOPOLOGY STRUCTURAL OPTIMIZATION PROBLEM STATEMENT FOR ROLLING STOCK AND SPECIAL EQUIPMENT OF RAILWAY

Nauka ta progres transportu, 2013
Purpose. The main paper purpose is the development of the topology structural optimization scientific basis regarding to the complicated optimization problems of rolling stock and special railway equipment structures. Methodology.
B. M. Tovt
doaj  

Microscopic stress-constrained two-scale topology optimisation for additive manufacturing

Virtual and Physical Prototyping
The extraordinary mechanical properties of additive manufactured two-scale lattice structures can be substantially enhanced by employing optimisation techniques at both macroscopic and microscopic scales.
Xiaopeng Zhang, Zheng Ni, Akihiro Takezawa, Yaguang Wang, Zhan Kang   +4 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Topology Optimization with Explicit Components Considering Stress Constraints

Applied Sciences
Topology optimization focuses on the conceptual design of structures, characterized by a large optimization space and a significant impact on structural performance, and has been widely applied in industrial fields such as aviation and aerospace. However,
Yubao Ma, Zhiguo Li, Yuxuan Wei, Kai Yang   +3 more
doaj   +1 more source