Results 41 to 50 of about 227,909 (262)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Partitioned Topology Optimization of Aero-Engine Rear Cooling Plate Based on Multi-Feature K-Means Algorithm

Aerospace
As a core load-bearing component, the aero-engine rear cooling plate requires its design to simultaneously meet strength requirements and lightweight indicators.
Huanhuan Chen, Jianqiang Jiang, Lizhang Zhang, Dong Mi, Shumin Ai, Haowei Guo   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Motherhood, stress and the exercise experience: freedom or constraint?

Leisure Studies, 2004
Lack of leisure and time to self have been found to be major stressors for mothers. This paper examines perceived stress‐relieving benefits gained from involvement in a 12 week exercise class program by a group of mothers (n = 30, x age = 37.3 years).
openaire   +3 more sources

Block aggregation of stress constraints in topology optimization of structures [PDF]

WIT Transactions on The Built Environment, Vol 91, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
José París, Fermín Navarrina, I. Colominas, M. Casteleiro   +3 more
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Packing Approach to Generate Void Structures in Lightweighted Parts for Additive Manufacturing

Mathematics
This paper presents a topology optimization approach that enables the creation of void structures that reduce part weight while meeting stress constraints for additive manufacturing, using an optimization packing problem.
Jose Antonio Marmolejo-Saucedo, Yuriy Stoyan, Georgiy Yaskov, Igor Litvinchev, Andrii Chuhai, Tetyana Romanova, Yurii E. Stoian   +6 more
doaj   +1 more source

Continuum structural topological optimizations with stress constraints based on an active constraint technique [PDF]

International Journal for Numerical Methods in Engineering, 2016
SummaryStress‐related problems have not been given the same attention as the minimum compliance topological optimization problem in the literature. Continuum structural topological optimization with stress constraints is of wide engineering application prospect, in which there still are many problems to solve, such as the stress concentration, an ...
Rong, Jian Hua, Xiao, Ting Ting, Yu, Liao Hong, Rong, Xuan Pei, Xie, Ya Jun   +4 more
openaire   +1 more source