Results 41 to 50 of about 5,046,540 (331)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Use of Mohr Diagrams to Predict Fracturing in a Potential Geothermal Reservoir
Geosciences, 2021 Inferences have to be made about likely structures and their effects on fluid flow in a geothermal reservoir at the pre-drilling stage. Simple mechanical modelling, using reasonable ranges of values for rock properties, stresses and fluid pressures, is ...
D.C.P. Peacock +2 more
doaj +1 more source
Two-scale approach to dynamic localization failure of AISI 316H stainless steel sheets [PDF]
Theoretical and Applied Mechanics, 2008 Dynamic localization failure of a thin sheet made of AISI 316H steel is considered on the macroscopic and mesoscopic level for proportional and nonproportional stress paths. On the macroscopic level, we propose: (1) the replacement of time as independent
Gambin W. +3 more
doaj +1 more source
Учёные записки Казанского университета: Серия Физико-математические науки, 2022 Based on the experimental-computational approach, a method for identifying deformation diagrams of elastoplastic materials by considering the inhomogeneity of the stress-strain state and large deformations was developed.
V.G. Bazhenov, E.V. Nagornykh
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Acceleration of the Antarctic Circumpolar Current by Wind Stress along the Coast of Antarctica [PDF]
, 2013 The influence of wind forcing on variability of the Antarctic Circumpolar Current (ACC) is investigated using a series of eddy-permitting ocean–sea ice models.
Zika, Jan D. +5 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Combined load simulation vs component loads simulation in machine design: A case study [PDF]
FME Transactions, 2014 At a present level of technology, almost all machine parts are subjected to combined loads in real working condition. The aim of research described in this paper is to highlight the importance of combined load simulation for the calculation of machine ...
Momčilović Dejan B. +3 more
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