Results 121 to 130 of about 4,440,265 (263)

Mental Health in Self-Quarantined Pregnant Women for 14 Days During the Coronavirus Outbreak in Iran

Iranian Journal of Nursing and Midwifery Research
Background: Quarantine during COVID-19 disease may be associated with psychological distress and other behavioral problems. This study aimed to investigate depression, anxiety, and stress in self-quarantined pregnant women at home for 14 days during the ...
Nasrin Ghiasi, Robab Kazempour, Arezoo Haseli, Mohammad Reza Kaffashian, Shayesteh Jahanfar   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Emotional burden and psychological distress in caregivers of patients with obsessive compulsive disorder

Khyber Medical University Journal
Objective: To explore the prevalence and association of emotional burden with anxiety, depression, and stress among caregivers of patients with Obsessive-Compulsive Disorder (OCD) in Southern Punjab, Pakistan.
Hafiz Shafique Ahmed, Khizra Iqbal, Farah Rasheed, Ali Waqas, Aleeza Javaid, Rashida Rehana   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Factor structure of acute stress disorder symptoms in Chinese earthquake victims: A confirmatory factor analysis of the acute stress disorder scale

, 2010
This study examined the factor structure of the acute stress disorder scale (ASDS; Bryant, Moulds, & Guthrie, 2000), a self-report measure for acute stress disorder (ASD).
Wang, Li, Zhongquan Li, Zhang, Yuqing, Li, Zhongquan, Shi, Zhanbiao, Shen, Jianhuan   +5 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Role of Affective-Emotional Temperament in Anticipation of Post-Traumatic Stress Disorder Symptoms in Maimed Individuals Caused by Mine Explosion

طب جانباز, 2017
Aims: Post-Traumatic Stress Disorder (PTSD), is one of the most common, chronic and debilitating psychiatric disorders that occurs after encountering a traumatic event.
M. Shafiei, S. Basharpoor, H. Heidarirad
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Prevalence of Post-Traumatic Stress Disorder Caused by War in Veterans

طب جانباز, 2017
Aims: The post-traumatic stress disorders sometimes continue years after wars. The aim of the study was to estimate the prevalence of post-traumatic stress disorders in the veterans 26 years after the end of Iran-Iraq war.
A.M. Rahnejat, P. Dabagi, M. Rabiei, A. Taghva, H. Valipoor, V. Donyavi, M.R. Ebrahimi   +6 more
doaj