Results 121 to 130 of about 3,700,086 (303)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Corrigendum: Acceleration of Debris Flow Due to Granular Effect

open access: yesFrontiers in Earth Science, 2021
Taiqiang Yang   +11 more
doaj   +1 more source

In-Plane Structural Analysis of Coated Masonry Walls via a Homogenized Model

open access: yesApplied Sciences
An orthotropic homogenized model is used to investigate the in-plane elastic behavior of coated masonry walls. The homogenization process mainly consists of modeling the elementary cell of a three-layer medium by using suitable designed assemblies of in ...
Simona Di Nino, Angelo Luongo
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Research on filling, pressure relief, and rock burst prevention in horizontal sublevel fully mechanized top coal caving of near-vertical coal seam groups

open access: yesGong-kuang zidonghua
Current rock burst prevention measures for near-vertical coal seam mining primarily include blasting, hydraulic fracturing, and the establishment of protective layers.
WANG Ziwei   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Localised stress and strain distribution in sliding

open access: yesScripta Materialia
In this paper, we present a comprehensive analysis of the contact mechanics associated with a micron-sized sliding asperity, which plays a crucial role in the abrasive wear processes. Utilising nanoscratch testing, we experimentally investigate the deformation and employ High-Resolution Electron Backscatter Diffraction (HR-EBSD) to characterise the ...
Anna Kareer   +3 more
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

THE STRESS DISTRIBUTION IN WELDS [PDF]

open access: yesProceedings of the National Academy of Sciences, 1930
openaire   +2 more sources

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