Results 231 to 240 of about 9,747,200 (282)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Coupling critical nitrogen dilution curve with hyperspectral feature optimization and machine learning for inversion of nitrogen nutrition index in greenhouse cucumber. [PDF]

Front Plant Sci
Zhao T, Li J, Hu C, Zhang D, Zhang G, Xu Y, Xiu W.   +6 more
europepmc   +1 more source

Erosion-driven delayed warming and marine stress prior to the end-Permian mass extinction. [PDF]

Nat Commun
Li S, Shen J, Grossman EL, Zhang S.
europepmc   +1 more source

Isotropic components of microseismic moment tensors at Utah FORGE reveal a diversity of fluid pathway creation processes in EGS development. [PDF]

Sci Rep
Niemz P, Petersen G, Rutledge J, Whidden K, Pankow K.   +4 more
europepmc   +1 more source

A method for collapse pressure analysis while drilling through fractured clay formations. [PDF]

Sci Rep
Zhuo C, Guojie C, Jian S, Guowei Z, Rongbin X.   +4 more
europepmc   +1 more source

Monitoring plant moisture content and optimizing irrigation prescriptions based on UAV multimodal data. [PDF]

Front Plant Sci
Fu W, Hou X, Wang D, Chen Z, Cheng Q, Li Y, Duan F.   +6 more
europepmc   +1 more source

An effective and accurate semi-implicit time integration scheme for dynamics in nearly- and fully-incompressible hyperelastic solids. [PDF]

J Comput Phys
Terrell EM, Davey M, Wells DR, Griffith BE.   +3 more
europepmc   +1 more source

Regression Analysis and Inversion Methods for Ground Stress Field Modeling in Underground Engineering

openaire   +1 more source