Results 41 to 50 of about 70,593 (290)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

An investigation of the perceived level of stress in various hotel supervisors and their preferred leisure activities [PDF]

open access: yes, 2000
Plan BThe purpose of this study was to investigate the perceived level of stress of hospitality supervisors and their choice of leisure activities. In doing so, there will be a greater understanding of leisure and the role it plays in decreasing the ...
Amin, Ayman M.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Full-field strain measurement and identification of composites moduli at high strain rate with the virtual fields method [PDF]

open access: yes, 2010
The present paper deals with full-field strain measurement on glass/epoxy composite tensile specimens submitted to high strain rate loading through a split Hopkinson pressure bar (SHPB) device and with the identification of their mechanical properties ...
MOULART, Raphaël   +15 more
core   +1 more source

Approximation of the crack-tip field in fatigue cracks in bridge steel specimens: DIC analysis of different constraint levels

open access: yesFracture and Structural Integrity, 2019
A study on the accuracy of the approximation of the displacement field around of crack tip in a sample made from bridge steel (S355) is main objective of contribution.
Stanislav Seitl   +5 more
doaj   +3 more sources

Study on the reconstruction of the paleo-tectonic stress field and its evolution in the Jinchuan mining district, Gansu Province, China

open access: yesDizhi lixue xuebao, 2023
The Jinchuan mining district has undergone a complex tectonic evolution history, and detailed analysis of the post-mineralization deformation characteristics and stress field evolution stages needs to be completed.
ZHAO Yuanfang, SHI Wei, ZHANG Yu
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Simulation Study on the Effect of Flue Gas on Flow Field and Rotor Stress in Gas Turbines

open access: yesEnergies, 2021
A flue gas turbine is the main energy recovery equipment in a heavy oil catalytic cracking unit. Blade erosion and fracture are the main reasons for gas turbine failure.
Guangkui Liu   +6 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy