Results 51 to 60 of about 359,894 (264)

3D MODELING OF STRESS FIELDS IN MILLING [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2015
Given the complexity of the physical phenomena present in machining, orthogonal cutting was the most exploited configuration in the analytical modelling of cutting.
Wadii YOUSFI, Raynald LAHEURTE, Philippe DARNIS, Olivier CAHUC, Madalina CALAMAZ   +4 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Review of Numerical Simulation Tools for Coupling Earth’s Interior and Lithospheric Stress Fields

Applied Sciences
As a bridge connecting processes in the Earth’s interior and the superficial lithosphere, distribution characteristics of global stress fields could benefit the verification of geodynamical models and reflect spatial variations of lithospheric strength ...
Danhua Zhang, Cheng Jiang, Xiaowen Lan, Jiayong Tian   +3 more
doaj   +1 more source

Hybrid-equilibrium elements with control of spurious kinematic modes

Computer Assisted Methods in Engineering and Science, 2023
A review is presented of a recent formulation of hybrid-equilibrium elements for modelling planar structural problems. The formulation is based on the use of polynomials of general degree to approximate internal stress fields and bounding side ...
Edward Anthony Ward Maunder, Jose Paulo Moitiniho de Almeida   +1 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Regional stress field of the Indian Plate

Geophysical Research Letters, 1985
We have calculated the regional stress field in the Indian plate, implementing dependence of slab pull and ridge push on the age of the oceanic lithosphere in the finite element procedure. The high level of the calculated stress field (order of a few kbar) and the dominance of compression in the plate are consequences of the unique dynamic situation of
Cloetingh, Sierd, Wortel, Rinus
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Self-Organization of Polymeric Fluids in Strong Stress Fields

Advances in Condensed Matter Physics, 2015
Analysis of literature data and our own experimental observations have led to the conclusion that, at high deformation rates, viscoelastic liquids come to behave as rubbery materials, with strong domination by elastic deformations over flow.
A. V. Semakov, V. G. Kulichikhin, A. Y. Malkin   +2 more
doaj   +1 more source