Results 81 to 90 of about 2,976,976 (292)

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress [PDF]

Journal of Diabetes Research, 2014
Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes. The mechanisms of this chronic pathogenic process are complex but have been suggested to involve production of reactive oxygen
openaire   +3 more sources

Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory

, 2018
Stress-associated mental disorders and diabetes pose an enormous socio-economic burden. Glucose dysregulation occurs with both psychosocial and metabolic stress.
Treccani, Giulia, Hasch, Annika, van der Kooij, Michael, Müller, Marianne B., Miederer, Isabelle, Voelxen, Nadine, Walenta, Stefan, Jene, Tanja   +7 more
core   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Association between stress hyperglycemia ratio and acute kidney injury development in patients with sepsis: a retrospective study

Frontiers in Endocrinology
BackgroundStress hyperglycemia ratio (SHR), which adjusts blood glucose levels using glycated hemoglobin to eliminate the influence of chronic hyperglycemia, has been demonstrated to have superior predictive value than absolute hyperglycemia.
Yipeng Fang, Aizhen Dou, Ying Zhang, Hui Xie, Yunfei Zhang, Yan Cui, Yan Cui, Keliang Xie, Keliang Xie   +8 more
doaj   +1 more source

Stress hyperglycemia: An essential survival response!

, 2013
Stress hyperglycemia is common in critically ill patients and appears to be a marker of disease severity. Furthermore, both the admission as well as the mean glucose level during the hospital stay is strongly associated with patient outcomes. Clinicians,
Marik, PE, Bellomo, R
core   +1 more source

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

BLOOD GLUCOSE LEVEL AND STRESS HYPERGLYCEMIA IN ACUTE ISCHEMIC STROKE [PDF]

, 2017
Objective: To determine the frequency of stress hyperglycemia and estimate the blood sugar level in patients with acute ischemic stroke. Patients and Methods: This cross sectional study of six months was conducted at tertiary care hospital Hyderabad. All
Khuda Bux Mangrio *, Dr. Rafi Ahmed Ghori , Dr. Naveed Aslam Lashari , Dr. Hamid Nawaz Ali Memon , Dr. Umair Ahmed Ghori , Dr. Sumera Bukhari and Dr. Zulfiqar Ali Qutrio Baloch
core   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source