Results 121 to 130 of about 1,437,569 (357)
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Cohesive zone models in history dependent materials [PDF]
, 2013 Copyright @ 2013 ACMECohesive zone model is a well known concept in nonlinear fracture mechanics of elasto-plastic materials. In contrast to that, we discuss a development of the cohesive zone model to linear, but time and history dependent, materials ...
Hakim, L, Mikhailov, SE
core +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Characterization of Residual Stress Effects on Fatigue Crack Growth of a Friction Stir Welded Aluminum Alloy [PDF]
An on-line compliance-based method to account for residual stress effects in stress-intensity factor and fatigue crack growth property determinations has been evaluated.
Blair, Amy +7 more
core +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
STRESS INTENSITY FACTORS FOR CIRCUMFERENTIAL PERIODIC CRACKED PIPES UNDER BENDING
Jixie qiangdu, 2019 Stress intensity factor is an important parameter that characterizes the stress field near the tip in fracture analysis. The simple and effective methods to estimate intensity factor become significant.
LIU WanJun, XIE YuJun
doaj
Stress-intensity factors for a thick-walled cylinder containing an annular imbedded or external or internal surface crack [PDF]
The elastostatic axisymmetric problem for a long thick-walled cylinder containing a ring-shaped internal or edge crack is considered. Using the standard transform technique the problem is formulated in terms of an integral equation which has a simple ...
Erdogan, F., Erdol, R.
core +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source