Results 121 to 130 of about 819,580 (307)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Cotton Blend Gravity $pp$ Waves [PDF]

open access: yes, 2004
We study conformal gravity in d=2+1, where the Cotton tensor is equated to a--necessarily traceless--matter stress tensor, for us that of the improved scalar field. We first solve this system exactly in the $pp$ wave regime, then show it to be equivalent
Deser, S., Jackiw, R., Pi, S. -Y.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Refined 3D Numerical Simulation of In Situ Stress in Shale Reservoirs: Northern Mahu Sag, Junggar Basin, Northwest China

open access: yesApplied Sciences
The shale oil reservoirs of the Lower Permian Fengcheng Formation in the northern Mahu Sag are promising targets. However, complex geology and strong heterogeneity in the area pose great difficulties in the numerical simulation of in situ stress fields ...
Peng Chen   +3 more
doaj   +1 more source

Fibular stress fracture in a female cross-country runner : a case report [PDF]

open access: yes, 2015
Stress fractures are probably the most feared class of injuries amongst endurance athletes, especially runners, since they require lengthy rehabilitation periods and temporary but drastic modifications of their training regime.
Micallef Stafrace, Kirill   +1 more
core  

Slow dynamics and stress relaxation in a liquid as an elastic medium

open access: yes, 2007
We propose a new framework to discuss the transition from exponential relaxation in a liquid to the regime of slow dynamics. For the purposes of stress relaxation, we show that a liquid can be treated as an elastic medium.
E. Orowan   +4 more
core   +1 more source

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