Results 111 to 120 of about 18,424 (327)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Effect of Heat-Treatment Time on Bending Properties of Cobolt-Chromium Orthodontic Wires [PDF]

, 2019
Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires.
Hammerbeck, Melanie
core   +1 more source

Heterogeneous integration of KY(WO4)2-on-glass : a bonding study [PDF]

, 2019
Rare-earth ion doped potassium yttrium double tungstate, RE: KY(WO4)(2), is a promising candidate for small, power-efficient, on-chip lasers and amplifiers. There are two major bottlenecks that complicate the realization of such devices.
Broquin, Jean-Emmanuel, Dijkstra, Meindert, Frentrop, Raimond, Garcia-Blanco, Sonia M., Ghibaudo, Elise, Kooijman, Roy, Muneeb, Muhammad, Roelkens, Günther, Segerink, Frans, van Emmerik, Carlijn I.   +9 more
core   +5 more sources

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Powder metallurgical materials and processes for soft magnetic applications [PDF]

, 2018
For many designers of electrical machines, the term “soft magnetic materials” automatically means laminated electrical sheet. This is unfortunate, since for many applications, particularly at low frequencies, laminated sheet is rarely the best material ...
Dougan, Mark J.
core  

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

The Effect of Heat Treatment and Cold Forging on the Mechanical Properties of SCr420 Low-Alloy Steel

Metals
This study developed a new heat treatment method, normalizing and stress relief (NSR), to increase productivity compared to spheroidizing annealing (SA).
Jaehan Lim, Soonhong Hwang, Sangwon Lee, Byounglok Jang   +3 more
doaj   +1 more source

Transforming Grain‐Boundary Brittle Precipitates to Ductility Pathways in Complex Concentrated Alloy

Advanced Science, EarlyView.
By engineering graded BCC/L12 interfaces, brittle precipitates in a complex concentrated alloy enable sequential deformation, realizing gigapascal strength with >20% elongation to solve the strength‐ductility trade‐off. ABSTRACT Conventional wisdom holds that hard grain‐boundary (GB) precipitates embrittle structural alloys by acting as crack ...
Zhixin Li, Xiao‐Tong Li, Zhaoqi Chen, Yushan Geng, Hao Gong, Sijia Hu, Wenli Song, Wanshun Xia, Chuanzheng Li, Linfa Peng, Yue Fan, Pengfei Guan, Bo Zhang, Weihua Wang, Yong Yang   +14 more
wiley   +1 more source

Residual stress and distortion analysis of laser powder bed additive manufactured parts using the incremental hole drilling method and the cantilever method

Journal of Advanced Joining Processes
This study investigates residual stresses and distortion in additively manufactured 316L austenitic steel and M350 martensitic high strength steel produced by laser powder bed fusion under varying process parameters.
Moritz Käß, Stefan Weihe, Martin Werz
doaj   +1 more source

A Strain Decoupling Packaging Strategy for High‐Fidelity Ultrathin Silicon Shape Sensors for Soft Medical Robotics

Advanced Science, EarlyView.
Reliable soft sensors are essential for precise control in soft medical robots such as endoscopes. We developed ultrathin silicon piezoresistive sensors and their oil‐lubricated slidable packaging, which enables high‐fidelity shape sensing of silicon gauges by mechanically isolating the sensing element within a dual‐layer film.
Hao Liu, Masahito Takakuwa, Michitaka Yamamoto, Yiwen Wang, Tomoyuki Yokota, Takao Someya, Toshihiro Itoh, Seiichi Takamatsu   +7 more
wiley   +1 more source