Results 131 to 140 of about 2,337,821 (336)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Discussion: “Experimental Investigation of Flow Resistance and Wall Shear Stress in the Interior Subchannel of a Triangular Array of Parallel Rods” (Fakory, M., and Todreas, N., 1979, ASME J. Fluids Eng., 101, pp. 429–434) [PDF]

, 1979
H.G. Lyall
openalex   +1 more source

Performance of rocket nozzle materials with several solid propellants [PDF]

Erosion resistance and thermal stress cracking tests of rocket nozzle materials with solid ...
Freche, J. C., Johnston, J. R., Signorelli, R. A.   +2 more
core   +1 more source

Reconstruction Mechanism of FCC Transition-Metal (001) Surfaces

, 1993
The reconstruction mechanism of (001) fcc transition metal surfaces is investigated using a full-potential all-electron electronic structure method within density-functional theory.
C. Elsässer, D. G. Fedak, D. Pettifor, D. Wolf, G. Benesh, K. Heinz, M. Bott, M. Lannoo, M. Mansfield, M. Methfessel, M. Methfessel, M. Methfessel, Matthias Scheffler, Michael Methfessel, N. Bickel, P. Pykkö, R. Dreizler, R. S. Mulliken, S. Hagstrom, V. Fiorentini, V. Heine, Vincenzo Fiorentini   +21 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

An Individual‐Level Analysis of the Stress‐Resistance Model of Household Mobility [PDF]

, 1984
Alan G. Phipps, Jacquelyn E. Carter
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The assembly process and co-occurrence network of soil microbial community driven by cadmium in volcanic ecosystem

Resources, Environment and Sustainability
Heavy metal (HM) contamination affects the composition and structure of soil microbial communities, but there are few studies on the assembly process and co-occurrence network of soil microbial community succession driven by Cd in volcanic ecosystem.
Qingchen Xiao, Boyan Wang, Zishan Li, Zihua Zhang, Kailing Xie, Jing Zhou, Keqing Lin, Xiaowan Geng, Xiaoyu Li, Jin Chen   +9 more
doaj   +1 more source

Controlling stress corrosion cracking in mechanism components of ground support equipment [PDF]

The selection of materials for mechanism components used in ground support equipment so that failures resulting from stress corrosion cracking will be prevented is described.
Majid, W. A.
core   +1 more source