Results 141 to 150 of about 2,417,663 (337)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Identification and Validation of qRT-PCR Reference Genes for Analyzing Arabidopsis Responses to High-Temperature Stress

Current Issues in Molecular Biology
Quantitative real-time PCR (qRT-PCR) is an essential tool for analyzing and selecting stable reference genes. In order to screen for suitable reference genes under high-temperature stress conditions in Arabidopsis, this study measured the relative ...
Siyu Chen, Qi Cai, Peipei Liu, Jingru Liu, Guanzhou Chen, Hanwei Yan, Han Zheng   +6 more
doaj   +1 more source

The role of endoplasmic reticulum stress in hippocampal insulin resistance

, 2016
Catrina Sims‐Robinson, Anna Bakeman, Rebecca Glasser, Janet M. Boggs, Crystal Pacut, Eva L. Feldman   +5 more
openalex   +1 more source

Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance [PDF]

, 2022
Jirapat Dawan, Juhee Ahn
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Advances in the molecular mechanism of grapevine resistance to fungal diseases

Molecular Horticulture
Grapevine is an important economic fruit tree worldwide, but grape production has been plagued by a vast number of fungal diseases, which affect tree vigor and the quality and yield of berries.
Zhi Li, Ronghui Wu, Fangying Guo, Yuejin Wang, Peter Nick, Xiping Wang   +5 more
doaj   +1 more source

Madforwater: Wp3: Adaptation Of Technologies For Efficient Water Management And Treated Wastewater Reuse In Agriculture: Task3.1: Reduction Of Crop Water Requirement And Tools For Irrigation Management With Treated Ww: Subtask 3.1.1: Plant Growth Promotion (Pgp) Bacteria To Enhance Crop Resistance To Water Stress And Salinity: Subset1

, 2018
Mahjoubi
openalex   +1 more source

The Role of Serendipita indica (Piriformospora indica) in Improving Plant Resistance to Drought and Salinity Stresses [PDF]

, 2022
Mohammad Reza Boorboori, Haiyang Zhang
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic Basis of Tillering Angle from Other Plants to Wheat: Current Progress and Future Perspectives

Plants
Plant architecture is an important agronomic trait that impacts crop yield. The tiller angle is a critical aspect of the plant’s structural organization, which is influenced by both internal and external factors.
Xiaohong Chen, Tingshu Lei, Yuming Yan, Mengyu Sun, Tao Zhong, Baolin Wu, Hanxi Liu, Chao Zhang, Fengli Sun, Yajun Xi   +9 more
doaj   +1 more source