Results 161 to 170 of about 8,553,788 (398)
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Multivariate Analysis Compares and Evaluates Heat Tolerance of Potato Germplasm
PlantsHigh temperature is the most important environmental factor limiting potato (Solanum tuberosum L.) yield. The tuber yield has been used to evaluate the heat tolerance of some potato cultivars, but potato yield was closely correlated with the maturation ...
Sujie Zhang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Discussion: “Experimental Investigation of Flow Resistance and Wall Shear Stress in the Interior Subchannel of a Triangular Array of Parallel Rods” (Fakory, M., and Todreas, N., 1979, ASME J. Fluids Eng., 101, pp. 429–434) [PDF]
, 1979 H.G. Lyall
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Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
RXLR effector genes mediate regional adaptation of Phytophthora infestans
Phytopathology ResearchLocal adaptation has been a central theme of eco-evolutionary research for decades. It is generally assumed that plant pathogens are locally adapted due to their standing interactions with biotic and abiotic factors in the ecosystem.
Jie Zheng +6 more
doaj +1 more source
Treatment increases stress-corrosion resistance of aluminum alloys [PDF]
, 1966 Overaging during heat treatment of the aluminum alloys immediately followed by moderate plastic deformation, preferably by shock loading achieves near optimum values of both yield strength and resistance to stress corrosion.
Jacobs, A. J.
core +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
The Molecular Genetics of Resistance: Resistance as a Response to Stress
The Florida Entomologist, 1995 In this overview of the molecular genetics of resistance, pesticides are regarded as one of the many environmental stresses against which insects must defend themselves to survive. Examined at the genetic level, pesticide resistance appears to be a preadapted response to stress and not due to novel mutations caused by pesticide exposure.
openaire +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source