Results 161 to 170 of about 2,387,231 (339)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

qPH1.01, a dominant QTL that contributes to plant height and ear height in maize

open access: yesThe Plant Genome
Plant height (PH) is an important agronomic trait closely related to yield and lodging resistance. In this study, bulked segregant analysis coupled with next‐generation sequencing (BSA‐seq) approach was employed to identify quantitative trait loci (QTLs)
Chuan Chen   +8 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

RXLR effector genes mediate regional adaptation of Phytophthora infestans

open access: yesPhytopathology Research
Local adaptation has been a central theme of eco-evolutionary research for decades. It is generally assumed that plant pathogens are locally adapted due to their standing interactions with biotic and abiotic factors in the ecosystem.
Jie Zheng   +6 more
doaj   +1 more source

Non-alcoholic fatty liver disease and insulin resistance are associated with increased cardiac oxidative stress in mice [PDF]

open access: bronze, 2013
Tomáš Jeleník   +8 more
openalex   +1 more source

Thermal Adaptation and Stress Resistance in <em>D. subobscura</em> Populations from Two Altitudes at Stara Planina Mountain (Serbia)<sup> </sup>

open access: hybrid, 2021
Katarina Erić   +6 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Effect of exposure cycle on hot salt stress corrosion of a titanium alloy [PDF]

open access: yes
The influence of exposure cycle on the hot-salt stress-corrosion cracking resistance of the Ti-8Al-1Mo-1V alloy was determined. Both temperature and stress were cycled simultaneously to simulate turbine-powered aircraft service cycles.
Gray, H. R., Johnston, J. R.
core   +1 more source

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